疫情嚴重,注意健康,加油
2019-2020相關資料文獻整理
#新型冠狀病毒和黑種草油的科學研究
2019-nCoV & Nigella Sativa Science
Researches
#林博士聲明: 2020.01.28
1.本文為本人整理編寫的原創文獻醫學文稿,重要內容均注明原文出處(或網路連結)若有疏漏,敬請指正。
(一)#抗病毒作用-正義單鏈RNA病毒
Antiviral effect-positive and single stranded RNA virus
- 2019新型冠狀病毒(Novelcoronavirus),世界衛生組織命名縮寫為2019-nCoV、武漢肺炎(Wuhanpneumonia)等。2019新型冠狀病毒與2003年4月在亞洲爆發SARS,SARS-CoV都是正義單鏈RNA病毒(positivesinglestrandedRNAvirus),這類病毒還包括人類的C型肝炎病毒(HepacivirusC)。
黑種草油(子)迄今並無抗冠狀病毒的研究。但臨床研究顯示黑種草油可以抗C型肝炎病毒(30名C肝病患),降低體內病毒載量。
埃及30名患有C型肝炎病毒(HCV)感染患者,未經甲型干擾素(α-Interferon)治療,每天餐後食用黑種草油,每日3次,連續服用3個月後,可顯著改善HCV病毒載量(380808.7±610937vs147028.2±475225.6,P=0.001)和提高體內總抗氧化能力TAC(1.35±0.5vs1.612±0.56, P=0.001),與下列實驗室參數得到改善:總氮蛋白、白蛋白、紅血球細胞數、血小板計數和下肢水腫等臨床狀況指數。
1.Barakat, EmanMahmoud Fathy, Lamia Mohamed El Wakeel, and RadwaSamir Hagag. "Effects of Nigella sativa on outcome of hepatitis C in Egypt." World journal of gastroenterology: WJG 19.16 (2013): 2529.
2.Oyero, OlufunmilayoG., et al. "Selective inhibition of hepatitis c virus replication by Alpha-zam, a Nigella sativa seed formulation." African journal of traditional, complementary and alternative medicines 13.6 (2016): 144-148.
(二) #免疫調節-提高巨噬細胞和樹突狀細胞作用.
*Immunomodulatory effects
- 研究顯示:黑種草油或其活性成分百里醌(TQ,Thymoquinone)可以調節免疫力(Th1和Th2),提高巨噬細胞(macrophage)和樹突狀細胞(dendriti)作用,顯示出有效的抗發炎作用。
黑種草油可增加吞噬活性(吞噬率56.83±6.37%)和吞噬指數(5.18±0.39),巨噬細胞分泌IL-12(最高水平在66.33±2.11μM)和TLR4的表達。數據通過單因子變異數分析(One-wayANOVA)進行統計學檢驗,顯著性為95%。
1.Akrom, Akrom, and MustofaMustofa. "Black cumin seed oil increases phagocytic activity and secretion of IL-12 by macrophages." Biomedical Research 28.12 (2017): 5241-5246.
2.Finlay, Trisha M., et al. "Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo." Glycoconjugate journal 27.6 (2010): 583-600.
3.Salem, Mohamed Labib. "Immunomodulatory and therapeutic properties of the Nigella sativa L. seed." International immunopharmacology 5.13-14 (2005): 1749-1770.
(三) #善肺部發炎症狀和損傷
Improve lung inflammation and injury
- 動物研究顯示:黑種草和其提取物或百里醌(TQ)對氣管反應和肺部炎症有預防作用,黑種草油可顯著降低因高氧吸入引起的肺損傷。
●黑種草的百里醌(TQ,thymoquinone)治療致敏組動物,可顯著善其肺部病理變化,降低其IL-4水平(p<0.05至p<0.001),增加其IFN-γ水平(p<0.001)。
●黑種草治療可抑制炎症性肺反應,顯著降低(p<0.05)支氣管周炎性細胞浸潤、肺泡中隔浸潤、肺泡水腫 肺泡滲出液、肺泡巨噬細胞和間質纖維化,肉芽腫和壞死形成。
●在組織病理學和免疫化學評估中,高氧+ 黑種草組的肺損傷嚴重程度明顯降低(P <.05),GSH-Px(穀胱甘肽氧化物酶)和SOD(超氧化物歧化酶)水平得到顯著保留MDA(血清脂質過氧化物)和MPO(骨髓過氧化酶)水平顯著低(P <.05)。
1.Boskabady,MohammadHossein,etal."TheeffectofNigellasativaextractontrachealresponsivenessandlunginflammationinovalbumin-sensitizedguineapigs."Clinics66.5(2011):879-887.
2.Keyhanmanesh,Rana,etal."Effectofthymoquinoneonthelungpathologyandcytokinelevelsofovalbumin-sensitizedguineapigs."Pharmacologicalreports62.5(2010):910-916.
3.Kanter,Mehmet."EffectsofNigellasativaseedextractonamelioratinglungtissuedamageinratsafterexperimentalpulmonaryaspirations."Actahistochemica111.5(2009):393-403.
4.Tayman,Cuneyt,etal."ProtectiveeffectsofNigellasativaoilinhyperoxia-inducedlunginjury."ArchivosdeBronconeumología(EnglishEdition)49.1(2013):15-21.
(四) #解呼吸道發炎症狀
Relief the symptoms of respiratory tract infection
- 多篇人體臨床研究:黑種草油可顯著緩解咽喉炎或扁桃腺炎的咽喉腫痛,補充黑種草油可改善哮喘和肺功能。黑種草的精油成分可抑制氣管收縮和增加黏膜纖毛的清除率。
●186位急性咽喉炎測試者,每天3次連續7天服用黑種草油和珠草萃取物,可完全緩解他們的咽喉腫痛,減少對止痛藥的需要。
●抗效喘和擴張氣管
80名哮喘患者的隨機,雙盲,安慰劑對照試驗,每天食用黑種草油兩次,連續4週,NSO組的平均哮喘控制測試得分顯著提高了21.1(標準差= 2.6)和19.6(標準差= 3.7)(p = 0.044),血液中的嗜酸性粒細胞減少了-50 (-155至-1)對15(-60至87)個細胞/μL(p = 0.013)。
29例哮喘成年患者隨機分為對照組和研究組,研究組給予每天口服黑種草提取
物,研究3個月後顯著改善哮喘症狀的頻率/週,胸部喘息和肺功能測試(PFTs)
值顯著改善(P <0.05到P <0.001),與對照組相比有顯著差異(P <0.01到P <0.001)。
在15例哮喘患者,黑種草萃取物對哮喘的氣道(airways)具有相對強效的抗喘效果(支氣管擴張)。
●天然氣管擴張劑,抑制氣管收縮和增加黏膜纖毛的清除2010年歐洲藥用植物和天然產品研究雜誌《Planta Medica》研究:黑種草的精油活性成分-百里醌(TQ) 、黑種草酮(Nigellone)是優於哮喘的吸入性氣管擴張藥fluticasone(屬類固醇類),賦予哮喘和過敏症患者帶來希望。
2008年歐洲藥用植物和天然產品研究雜誌《Planta Medica》研究表明:黑種草油的精油成分黑種草酮(Nigellone)和百里醌(TQ)可用於治療不同的呼吸系統疾病,可緩解氣管的痙攣和增加黏膜纖毛的清除率。
1.Dirjomuljono, M., et al. "Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruriextract." International journal of clinical pharmacology and therapeutics 46.6 (2008): 295-306.
2.Koshak, Abdulrahman, et al. "Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial." PhytotherapyResearch 31.3 (2017): 403-409.
3.Boskabady, Mohammad Hossein, et al. "The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients." Fundamental & clinical pharmacology 21.5 (2007): 559-566.
4.Boskabady, M. H., N. Mohsenpoor, and L. Takaloo. "Antiasthmaticeffect of Nigella sativa in airways of asthmatic patients." Phytomedicine 17.10 (2010): 707-713.
5.Keyhanmanesh, Rana, et al. "The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs." Planta medica 76.03 (2010): 218-222.
6.Wienkötter, N., et al. "The effect of nigelloneand thymoquinone on inhibiting trachea contraction and mucociliaryclearance." Planta medica 74.02 (2008): 105-108.
#薑黃文獻研究
●#薑黃的薑黃素抑制所有C型肝炎病毒基因型進入人肝細胞
Colpitts, Che C., et al. "Turmeric curcumin inhibits entry of all hepatitis C virusgenotypes into human liver cells." Gut 63.7 (2014): 1137-1149
●#薑黃素在病毒性急性呼吸窘迫綜合症的老鼠模中,調節發炎症反應並抑制隨後的纖維化
Avasarala, Sreedevi, et al. "Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome." PloSone 8.2 (2013).
●#薑黃素通過減輕肺損傷和調節巨噬細胞細胞因子產生來減輕嚴重的流感性肺炎
Han, Shuguang, et al. "Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production." Clinical and Experimental. Pharmacology and Physiology 45.1 (2018): 84-93.
#蜂蜜文獻研究
●2014年一項基於前瞻性隊列研究:以蜂蜜做保守療,35%的慢性C型肝炎病毒患者可持續清除C肝炎病毒
KOTB, MAGD A., and AHMED K. ABDALLA. "Sustained Hepatitis C Virus Clearance was Achieved by Honey Based Conservative Management in 35% of Chronic Hepatitis C Virus Patients: A Prospective Cohort Study." Interferon 8: 10.
●蜂蜜與健康:近期臨床研究述評-蜂蜜具抗發炎免疫調節活性、減少咳嗽、發燒和減輕哮喘相關症狀
Samarghandian, Saeed, TaherehFarkhondeh, and FariborzSamini. "Honey and health: A review of recent clinical research." Pharmacognosy research 9.2 (2017): 121.)
#食用建議
#黑種草油5ml + #蜂蜜10ml +#薑黃粉(#或薑黃素)適量
❗每日2次❗
#黑種草油、#蜂蜜和薑黃
都有抗單股RNA病毒、抗發炎、減少肺部發炎症狀,調節免疫力和增加抵抗力的效果,非常適合這個季節做為每日保健的補充劑。
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【都市隱疾】很多人受痔瘡困擾
⭐別怕尷尬而拒絕治療
⭐日常調護從飲食開始
#星期四食材
暢便水果一覽
常說「十個男人九個痔」,其實痔患無分男女,尤其工作忙碌、壓力大、長時間坐着、飲食多肉少菜、多吃刺激性食物人士,生痔瘡的機會較高。痔瘡形成初期排便會輕微出血、擦拭肛門時衛生紙有血跡、無疼痛感,在這個階段可先透過改善飲食習慣自救:多進食蔬菜、水果,尤其有潤腸通便功效的水果以紓緩症狀。如果痔瘡出血、脫垂、血栓疼痛等情況就必須就醫治理,病情嚴重除引致疼痛,亦會造成貧血等情況。
麒麟果 — 性涼,有清熱生津、潤腸通便的功效,由於麒麟果有比火龍果更豐富的粗纖維與果糖,因此對便秘特別有紓緩作用,腸胃虛弱及易有便溏的人多吃會出現腹瀉。要注意麒麟果糖分相對較高,糖尿病患者不宜多吃。
火龍果 — 性涼,有清熱生津、潤腸通便的功效,適合內熱較重、陰虛火旺、煩躁口乾、痔瘡便秘人士食用。紅肉和白肉火龍果功效相若。
無花果 — 性平,有潤腸通便、健胃利咽、滋陰潤燥、催乳功效,對老年人、孕婦、小兒便秘有明顯療效,孕婦食用亦可預防痔瘡。惟其糖份含量較高,糖尿病患者慎吃。
香蕉 — 生香蕉屬性寒涼,熟香蕉或經烹煮的香蕉寒性會減低,有清熱通便、解酒功效,適合大便乾燥、痔瘡、大便出血者食用。但要注意尚青或沒熟透的香蕉有收斂作用,能止瀉更有可能引起便秘。
木瓜 — 性平,能健脾胃,幫助消化,消暑解渴。適合脾胃虛弱,容易胃脹不適人士服用,能紓緩食慾下降、消化不良、胃部不適、產婦乳汁不足等症狀。注意孕婦不宜食用。
水蜜桃 — 性熱,有補益氣血、養陰生津、潤腸的作用,適合低血糖、心血不足、肺虛喘咳者食用。由於屬性溫熱,易生熱助火,體內有偏熱症狀不宜多吃,糖尿病患者及血糖偏高者不宜吃。
✔ CheckCheckCin茶療推介:火龍果玫瑰茶
材料:紅火龍果、冰糖、蜂蜜、玫瑰花、檸檬及白毫烏龍
功效:疏肝解鬱,潤腸通便,適合大便不暢、有壓力、經常嘆氣、暗啞肌膚人士。
注意:適合月經前飲用;月經期間、孕婦不宜。
✔CheckCheckCin米水推介:燕麥米水
材料:紅米、白米、燕麥
功效:去水腫、紓緩便秘、改善多汗
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Fruits that can promote bowel movement
There is a common saying ‘nine out of ten men have hemorrhoid’. There is a high chance for individuals who are busy at work and under a lot of pressure, as well as those who sit down for long hours, eat more meat than vegetables, and enjoy consuming food that irritates the body to develop hemorrhoid.
During the early stages of hemorrhoid, individuals would see blood when they are passing stool. Traces of blood can be found but generally painless. At this stage, individuals can try to salvage the situation by improving their dietary habits.
Consume more vegetables and fruits, especially those that can improve bowel movement to relieve the hemorrhoid symptoms. If it becomes a prolapsed hemorrhoid, a thrombosed hemorrhoid, and bleeding happens, we must get proper medical treatment. If the situation becomes more serious, an individual might not only experience pain but also anemia.
Yellow dragon fruit - cool in nature, can clear heat and promote fluid production, moisten the intestines to relieve constipation. Yellow dragon fruit is higher in fiber and is especially effective in relieving constipation. Those with asthenic weak spleen and stomach or prone to loose stool may experience diarrhea after eating. Yellow dragon fruit is also higher in sugar content so it is not suitable for those with diabetes.
Dragon fruit - cool in nature, can clear heat and promote fluid production, moisten bowel to relieve constipation and relieve thirst. It is suitable for those with inner heat, yin deficiency with excess fire, hemorrhoids and constipation. Similar effects to regular white or red meat dragon fruit.
Figs - mild in nature, can moisten intestine to relieve constipation, strengthen the stomach, relieve sore throat, nourish yin and relieve dryness, aid in lactation. It is especially effective in treating constipation for elderlies, pregnant women and young children. Pregnant women can prevent hemorrhoids by eating figs. However, its sugar content is high, so diabetic patients should be cautious in taking it.
Banana - unripe banana is cool in nature, cold nature is reduced when it is ripe or cooked. It can clear heat, relieve constipation and hangover. Suitable for those who have dry stool, hemmeroid and stool bleeding. Note that green and unripe bananas can induce astringency, relieve diarrhea or lead to constipation.
Papaya - mild in nature, can strengthen the spleen and stomach and aid digestion. Papaya can clear summer heat and relieve thirst even for those with asthenic spleen and stomach and prone to abdominal bloating. It can alleviate poor appetite, indigestion, stomach discomfort, and even improve milk supply for nursing mothers. Note that pregnant women should not have papaya.
Peach – hot in nature, can replenish qi and blood, nourish yin and promote saliva secretion, as well as stimulate bowel movements. It is suitable for individuals with low blood sugar level, heart-blood deficiency, the manifestation of cough and asthma caused by a weak lung. Individuals with heat related symptoms should not consume peach excessively, since it is hot in nature. The same goes for patients with diabetes and high blood sugar (hyperglycemia).
✔ CheckCheckCin Paper Pack Drink Recommendation: Dragon Fruit Rose Tea
Ingredients: Water, Dragon Fruit Juice, Rock Sugar, Honey, Rose, Lemon Juice Concentrate, Oolong Tea
Effects: Relieves stress, moistens the bowels to relieve constipation. Suitable for difficulty passing stool, stress, frequent sighs, and dull complexion.
Note: To relieve menstrual discomfort, have this tea 3-7 days before period. Not suitable for menstruating and pregnant women.
✔️CheckCheckCin Rice Water Recommendation: Oats Rice Water
Ingredients: Red Rice, White Rice, Oats
Effects: relieves symptoms of bloating or chubbiness, constipation, excessive sweating, night sweating and fatigue.
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#男 #女 #我有壓力
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(一)失眠為什麼成濕疹病人常見問題? 00:06
(二)為什麼濕疹常於晚上出現? 00:30
(三)濕疹的治療 01:10
(四)濕疹病人安眠錦囊 02:11
(本短片作健康教育之用,並不可取代任何醫療診斷或治療。治療成效因人而異,如有疑問,請向專業醫療人士諮詢。)
參考資料:
1. Hong Kong Asthma Society(2015). Pathology and causes of Eczema. Retrieved from https://hkasthma.org.hk/en/about-allergies/pathology-and-causes-0
2. Department of health (2020). Other Physical Health Problems. Retrieved from
https://www.studenthealth.gov.hk/tc_chi/health/health_ophp/health_ophp_tet.html
3. Bartlet LB, Westbroek R, White JE. Sleep patterns in children with atopic eczema. Acta Derm Venereol. 1997 Nov;77(6):446-8. doi: 10.2340/0001555577446448. PMID: 9394978.
4. Li JC, Fishbein A, Singam V, et al. Sleep Disturbance and Sleep-Related Impairment in Adults With Atopic Dermatitis: A Cross-sectional Study. Dermatitis : Contact, Atopic, Occupational, Drug. 2018 Sep/Oct;29(5):270-277. DOI: 10.1097/der.0000000000000401.
5. Camfferman D, Kennedy JD, Gold M, Martin AJ, Lushington K. Eczema and sleep and its relationship to daytime functioning in children. Sleep Med Rev. 2010 Dec;14(6):359-69. doi: 10.1016/j.smrv.2010.01.004. Epub 2010 Apr 14. PMID: 20392655.
6. Chang, Y. S., & Chiang, B. L. (2016). Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin. International journal of molecular sciences, 17(4), 462. https://doi.org/10.3390/ijms17040462
7. Ozawa M, Tsuchiyama K, Gomi R, Kurosaki F, Kawamoto Y, Aiba S. Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis. J Am Acad Dermatol. 2009 Apr;60(4):609-14. doi: 10.1016/j.jaad.2008.11.900. PMID: 19178984.
8. Hong Kong Asthma Society(2015).Treatment option of Eczema. Retrieved from https://hkasthma.org.hk/en/about-allergies/treatment-option-eczema
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asthma treatment 在 [email protected] Youtube 的最佳解答
濕疹- 盧景勳皮膚科專科醫生@FindDoc.com
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(一)異位性皮膚炎是什麼? 00:07
(二)異位性皮膚炎成因? 00:39
(三)患上異位性皮膚炎需要戒口嗎? 01:13
(四)「濕疹鐵三角」可以治療異位性皮膚炎嗎? 2:20
(本短片作健康教育之用,並不可取代任何醫療診斷或治療。治療成效因人而異,如有疑問,請向專業醫療人士諮詢。)
參考資料:
1. Al-Shobaili, H. A., Ahmed, A. A., Alnomair, N., Alobead, Z. A., & Rasheed, Z. (2016). Molecular Genetic of Atopic dermatitis: An Update. International journal of health sciences, 10(1), 96–120.
2. Kanda, N., Hoashi, T., & Saeki, H. (2019). The Roles of Sex Hormones in the Course of Atopic Dermatitis. International journal of molecular sciences, 20(19), 4660. https://doi.org/10.3390/ijms20194660
3. Drislane, C., & Irvine, A. D. (2020). The role of filaggrin in atopic dermatitis and allergic disease. Annals of Allergy, Asthma & Immunology, 124(1), 36-43. doi:10.1016/j.anai.2019.10.008
4. Suárez, A. L., Feramisco, J. D., Koo, J., & Steinhoff, M. (2012). Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. Acta dermato-venereologica, 92(1), 7–15. https://doi.org/10.2340/00015555-1188
5. Dhar, S., & Srinivas, S. M. (2016). Food Allergy in Atopic Dermatitis. Indian journal of dermatology, 61(6), 645–648. https://doi.org/10.4103/0019-5154.193673
6. Yu, W. (2001). The Role of Food Allergy in Atopic Dermatitis in Children. Hong Kong Dermatology & Venereology Bulletin, 9(3), 110-116.
7. Lee, S. Y., Lee, E., Park, Y. M., & Hong, S. J. (2018). Microbiome in the Gut-Skin Axis in Atopic Dermatitis. Allergy, asthma & immunology research, 10(4), 354–362. https://doi.org/10.4168/aair.2018.10.4.354
8. Lee SY, Lee E, Park YM, Hong SJ. Microbiome in the Gut-Skin Axis in Atopic Dermatitis. Allergy Asthma Immunol Res. 2018 Jul;10(4):354-362. doi: 10.4168/aair.2018.10.4.354. PMID: 29949831; PMCID: PMC6021588.
9. Kim, H., Ban, J., Park, M. R., Kim, D. S., Kim, H. Y., Han, Y., Ahn, K., & Kim, J. (2012). Effect of bathing on atopic dermatitis during the summer season. Asia Pacific allergy, 2(4), 269–274. https://doi.org/10.5415/apallergy.2012.2.4.269
10. Ozkoca, Kutlubay, & Karakus. (2019). Treatment of Atopic Dermatitis: What’s New? Clinical Dermatology: Research and Therapy.
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asthma treatment 在 [email protected] Youtube 的最讚貼文
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(一)濕疹對日常生活有什麼影響? 00:06
(二)濕疹會誘發什麼併發症? 00:45
(三)濕疹有什麼治療方法? 01:29
(本短片作健康教育之用,並不可取代任何醫療診斷或治療。治療成效因人而異,如有疑問,請向專業醫療人士諮詢。)
參考資料:
1. Schonmann, Y., Mansfield, K. E., Hayes, J. F., Abuabara, K., Roberts, A., Smeeth, L., & Langan, S. M. (2020). Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study. The journal of allergy and clinical immunology. In practice, 8(1), 248–257.e16. https://doi.org/10.1016/j.jaip.2019.08.030
2. George SMC, Karanovic S, Harrison DA, Rani A, Birnie AJ, Bath‐Hextall FJ, Ravenscroft JC, Williams HC. Interventions to reduce Staphylococcus aureus in the management of eczema. Cochrane Database of Systematic Reviews 2019, Issue 10. Art. No.: CD003871. DOI: 10.1002/14651858.CD003871.pub3.
3. Sutherland M, Parent A. Cellulitis: Assessment, diagnosis and management. Dermatological Nursing 2017. 16(4): 24-28
4. Ekbäck M, Tedner M, Devenney I, Oldaeus G, Norrman G, Strömberg L, et al. (2014) Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years. PLoS ONE 9(6): e99609. https://doi.org/10.1371/journal.pone.0099609
5. Mayo Clinic. (2020). Atopic dermatitis (eczema). Retrieved from https://www.mayoclinic.org/diseases-conditions/atopic-dermatitis-eczema/diagnosis-treatment/drc-20353279
6. Meagher, L.J., Wines, N.Y. and Cooper, A.J. (2002), Atopic dermatitis: Review of immunopathogenesis and advances in immunosuppressive therapy. Australasian Journal of Dermatology, 43: 247-254. doi:10.1046/j.1440-0960.2002.00610.x
7. Deleanu, D., & Nedelea, I. (2019). Biological therapies for atopic dermatitis: An update. Experimental and therapeutic medicine, 17(2), 1061–1067. https://doi.org/10.3892/etm.2018.6989
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