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在journal of the chinese medical association sci這個產品中，有3篇Facebook貼文，粉絲數超過3萬的網紅新思惟國際，也在其Facebook貼文中提到， #張雁霖藥師課後第2篇論文 #最新梯次即將額滿 #新思惟學員天天有發表 腦外傷患者，由於可能會產生外傷後癲癇，臨床上有時會使用抗癲癇藥物做預防。不過，在實證上，到底抗癲癇藥物用於腦外傷，是不是真有預防癲癇的效果，目前資料不多。 張雁霖藥師團隊，預計使用臨床實際資料，回溯研究，並使用傾向分數匹...

journal of the chinese medical association sci 在 新思惟國際 Facebook 的精選貼文

新思惟國際 By 新思惟國際

2020-09-04 13:42:26 有 13 人按讚
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#張雁霖藥師課後第2篇論文
#最新梯次即將額滿
#新思惟學員天天有發表
　
腦外傷患者，由於可能會產生外傷後癲癇，臨床上有時會使用抗癲癇藥物做預防。不過，在實證上，到底抗癲癇藥物用於腦外傷，是不是真有預防癲癇的效果，目前資料不多。
　
張雁霖藥師團隊，預計使用臨床實際資料，回溯研究，並使用傾向分數匹配，盡量減少誤差，來回答這個問題。
　
研究收入了 2010 到 2017 年的 1316 位患者，並以傾向匹配分數，配出有使用抗癲癇藥物預防腦外傷後癲癇的 138 位患者，以及沒有使用抗癲癇藥物預防的 138 位患者。基本資料與臨床狀況都是類似。經過統計，兩組患者之後產生癲癇的機率並無顯著差異。
　
作者群認為，目前對於腦外傷患者，使用抗癲癇藥物以作癲癇預防的臨床作法，應該被重新評估。
　
這是個蠻有意思的研究，有些臨床上的應用，實證力量不見得很強，像是本例來說，在一般癲癇患者，使用抗癲癇藥有效，但腦外傷造成的癲癇，其機轉未必一樣，使用抗癲癇藥，是否真能有預防效果，的確難說。
　
如果能用真實數據回溯比較看看，得到一個大概的方向，除了能作初步發表，也能啟發未來研究的方向。
　
#期刊介紹
　
Journal of the Chinese Medical Association（JCMA、中華醫學會雜誌），之前稱為 Chinese Medical Journal (Taipei)，為中華醫學會的附屬期刊，辦公室設於台北榮總。
　
2008 年收錄於 SCIE (Science Citation Index Expanded)，JCMA 的 impact factor 從 2014 年的 0.845，逐步上升到 2019 年的 2.170，在 Medicine, General & Internal 領域排名為 Q2(63/165) 期刊。
　
🔔 2020 / 10 / 17（六）醫學論文與寫作工作坊　
名額僅剩幾席｜即將額滿
https://mepa2014.innovarad.tw/event/
　
💖 新思惟校友（月）論文發表再創新高 💖
🎉 登上 NEJM！🎉
　
太驚人了！太驚人了！
2020 年 8 月 PubMed (SCI) 追蹤_共有 68 位 (72 篇)。
　
以下是 2020 年 8 月這 72 篇的組成：
Original article x 46（Clinical 30, Basic 5, NHIRD 8, Meta-analysis 3）
Letter x 8
Review x4
Case report x 12
Image x 1
Editorial x1　
　
🔔 2020 / 10 / 17（六）醫學論文與寫作工作坊　
名額僅剩幾席｜立即報名
https://mepa2014.innovarad.tw/event/
　 　
前前後後跟著老師寫論文、跑統計、投稿，但有種不踏實的感覺嗎？
　
覺得實際上缺乏扎實的寫作方法論嗎？
　
對於投稿策略也沒有想太多，投稿常常被拒絕，寫論文越來越失去熱情，但又想成為一位獨立研究者，到底該怎麼做比較有效率？
　
✓ 不再害怕統計，讓你親手畫出數據圖，有。
✓ 入門稿件寫作與準備要訣，有。
✓ 投稿期刊選擇策略。多元文體與學術參與，有。
✓ 還是寫不出來？過來人時間安排建議，有！
　
內科 #陳一銘醫師，復健科 #吳爵宏醫師，放射科 #蔡依橙醫師，與你一樣的世代，超過 200 篇 SCI 發表經驗，給你最實用的建議。
　
🔔 近期校友傑出榮耀 #每天都有學員發表
https://mepa2014.innovarad.tw/greatachievements/
　
[快訊] 張譽耀醫師團隊，以糞便測試預測潰瘍性大腸炎黏膜癒合狀況之研究，獲 PeerJ 刊登！
　
[快訊] 陳建翰醫師團隊，關於減重手術後，以評分系統預測半年後體重下降幅度之研究，獲 Scientific Reports 刊登！
　
[快訊] 梁宗榮醫師團隊，關於胃造口管在更換時錯位之個案報告，獲 Gastrointestinal Endoscopy 刊登！
　
[快訊] 劉文智醫師團隊，報告兩例嚴重膝蓋外傷併發感染並重建成功之個案，獲 Journal of Orthopaedic Surgery (Hong Kong) 刊登！
　
[快訊] 李紹榕醫師團隊，關於混合式手術醫師作為微創時代的心臟手術主力之致編者信，獲 The Annals of Thoracic Surgery 刊登！
　
新思惟最受歡迎研究入門課程，論文苦手必上。
名額僅剩幾席｜立即報名
https://mepa2014.innovarad.tw/event/

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實用型互動工作坊 高品質大型研討會 http://www.innovarad.tw/
實用型互動工作坊 高品質大型研討會 (用「心」的新思「惟」)
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journal of the chinese medical association sci 在 健吾 Facebook 的最讚貼文

健吾 By 健吾

2019-11-24 05:58:41 有 577 人按讚
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睇晒佢。

112300 好想喊，多謝手足！

【文獻整合：產前後 (perinatal) 經母體接觸二噁英對兒童的影響】

撰文：香港人兒科醫生

關於二噁英的基本資料和毒性我就不再贅述了，詳細可以參閱 Dr K Kwong 所寫。我是兒科醫生，所以我參閱的文獻以二噁英對兒童的影響為主。 翻查 Pubmed，近年關於二噁英與兒童的研究，主要針對於產前後 (perinatal) 經母體接觸二噁英對兒童的影響。 這是因為發展中的胎兒對任何有神經毒性 (neurotoxic) 的物質最為敏感，所以理論上影響最大。 巧合的是，就在今年二月， 香港醫學雜誌 （Hong Kong Medical Journal) 就有一份關於香港兒童長達11年的跟進研究 [1]。 但大部分地區包括最近香港發表的研究都是針對 “background level of dioxin” 的影響，即是一般存在於環境的二噁英。 正常來說濃度不高，對嬰孩發展有短期，但無長期的惡性影響 [1-3]。

但問題是，我們現在是擔心被二噁英高度污染，所以參考越南當地的情況應該較適合。 研究人員發現，在受污染地區的媽媽體內的二噁英，比沒有受污染的地區高三至四倍 [4-5]。 研究發現，母親體內的二噁英含量越高，兒童的多方面發展越受到不利影響。 這包括：認知、語言、大小肌肉、身體協調和平衡、和讀寫能力 [5-8]。簡單來說，母親體內二噁英含量越高，兒童在以上各方面表現越差。 這個惡性影響，在跟進到八歲的小朋友身上依然見得到。 受影響的兒童以男孩為主 [6-9]。而且，有發現受影響兒童社交方面發展較弱，有自閉症譜系障礙的徵狀 [10]。

男孩子比較受母體二噁英的影響，又引伸到二噁英引致內分泌異常的問題。 胎兒會因為母親體內二噁英而影響到睪丸激素（testosterone)的分泌 [11-12]，而此激素的異常會影響胎兒腦部成長 （詳情太複雜，不詳述）。 二噁英亦會影響幼童的甲狀腺功能 [13]。

除了以上，還有兩點我覺得需要留意。 第一， 越南被橙劑 (Agent Orange) 毒害已經是多年前的事，但受污地區的婦女體內二噁英含量依然高。 亦有研究發現當年因為911事件世界貿易中心倒塌時釋出的二噁英污染物，經過十幾年後，當時在附近的兒童，體內二噁英含量依然比一般人明顯地高 [14]。 由此可見二噁英的毒害是可以影響深遠。

第二，絕大部分關於母嬰的研究，研究人員都是測量母乳內的二噁英含量做數據。這是因為二噁英是脂溶性的 (lipophilic)，在母乳的含量和身體積存的份量相約，而母乳是容易最獲得的樣本。 這亦表示，嬰孩會經由母乳繼續攝取二噁英。 世界衛生組織 （WHO）基於研究發現產前二噁英經胎盤對胎兒影響比產後經由母乳吸收影響為大，而且母乳有非常多的其他好處 （詳情請參考衛生署網頁）。 由於母乳餵哺的好處多於壞處，所以繼續建議母乳餵哺[15]。 但我認為婦女需要知道母乳含有二噁英這個事實，然後作決定 （informed choice)。

至於關於二噁英與胎兒先天性異常 （congenital abnormality) 和幼童/青少年的影響，我之後有時間/心機讀完書先再分享。

#香港人
#要平安
#記得去投票

1. Hui LL, Lam HS, Lau EY, NElson EA, Wong TW, Fielding R. Prenatal exposure to dioxins and subsequent neurocognitive and developmental function in Hong Kong Chinese children. Hong Kong Med J 2019 Feb;25 Suppl 3(1):35-39.

2. Koopman-Esseboom C, Weiglas-Kuperus N, Ridder MAJ, eat al. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants’ mental and psychomotor development. Paediatrics 1996;97:700-6

3. Nakajima S, Saijo Y, Kate S, eat al. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese child raven at 6 months of age. Environ Health jPerspect 2006;114:773-8

4. Tai PT, Nishijo M, Anh NT, Maruzeni S, Nakagawa H, Van Luong H, Anh TH, Honda R, Kido T, Nishijo H. Dioxin exposure in breast milk and infant neurodevelopment in Vietnam. Occup Environ Med. 2013 Sep;70(9):656-62.

5. Tai PT, Nishijo M, Kido T, et al. DIoxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicides spraying. Environ Sai Technology 2011;45:6625-32.

6. Pham NT, Nishijo M, Pham TT, Tran NN, Le VQ, GTran HA, Phan HAV, Nishijo Y, NIshijo H. Perinatal dioxin exposure and neurodevelopment of 2-year-old Vietnamese children in the most contaminated area from Agent Orange in Vietnam.

7. Tran NN, Pham TT, Ozawa K, Nishijo M, Nguyen AT, Tran TQ, Hoang LV, Tran AH, Phan VH, Nadia A, Nishijo Y, Nishijo H. Impacts of perinatal dioxin exposure on motor coordination and higher cognitive development in Vietnamese preschool children: a five-year follow-up. PLoS One 2016 Jan 29;11(1):e0147655.

8. Pham The T, Pham Ngoc T, Hoang Van T, Nishijo M, Tran Ngoc N, Viu Thi H, Hoang Van L, Tran Hai A, Nishijo Y, Nishijo H. Isn’t J Hyg EnvironHealth. 2019 Oct 3 pic:S1438-4639(19)30287-1.

9. Nakajima S, Saijo Y, Miyashita C, Ikeno T, Sasaki S, Kajiwara J, Kishi R. Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children: Sapporo cohort study. Environ Res 2017 Nov;159:222-231.

10. Nishijo M, Pham TT, Nguyen AT, Tran NN, Nakagawa H, Hoang LV, Tran AH, Morikawa Y, Ho MD, Kido T, Nguyen MN, Nguyen HM, Nishijo H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam. Mol Psychiatry 2014 Nov;19(11):1220-6.

11. Anh NTP, Kido T, Honda S, Obama Y, Anh LT, Phuket HD, Vietnam NH, Manh HD, Okamoto R, Nakagawa H, Nakayama SF, Nguyen DD, Van Tung D, Van Chi V, Minh NH, Van Tran N. Androgen disruption by dioxin exposure in 5-year-old Vietnamese children: Decrease in serum testosterone level. Sci Total Environ 2018 Nov 1;640-641:466-474.

12. Araki A, Mitsui T, Miyashita C, Nakajima T, Naito H, Ito S, et al. (2014) Association between maternal exposure to di (2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido study on environment and children’s health. PLOS ONE 9:e109039 10.1371/journal.pone.0109039

13. Baccarelli A, Giacomini SM, Corbetta C, Texas al. NEonatal thyroid function in sevens o 25 years after maternal exposure to dioxin. PLoS Med 2008;5:1133-42.

14. Kahn LG, Han X, Koshy TT, Shan Y, Chu DB, Kennan K, Transande L. Adolescents exposure to the World Trade Centre collapse have elevated serum dioxin and furan concentrations more than 12 years later. Environ Int 2018 Feb;111:268-278.

15. Van den Berg M, Kypke K, Kota A, Tritscher A, Lee SY, Magulova K, Fiedler H, Malisch R. WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding. ARCH Toxicol 2017 jan;91(1):83-96

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健吾

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著書42本，近作為《未敢忘記2019／20》，《關於香港，我無嘢講》，《903國?
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journal of the chinese medical association sci 在 港式執媽 Facebook 的最佳貼文

港式執媽 By 港式執媽

2019-11-23 02:15:17 有 83 人按讚
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多謝各界專業人士繼續出聲😭😭😭
好sad既係有醫生搵到文獻指母乳會傳送母體的二噁英比bb
而二噁英對小朋友發育影響深遠，去到8歲都仲見得到影響😭😭😭💔💔💔💔
好sad......香港政府毒害我地既下一代
🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿🖕🏿

#用選票擊退保皇黨
#放催淚彈果班垃圾都會自食惡果
#好傷心
#陳肇始無恥
#恥與為伍
#食衛局局長放棄全香港人健康

112300 好想喊，多謝手足！

【文獻整合：產前後 (perinatal) 經母體接觸二噁英對兒童的影響】

撰文：香港人兒科醫生

關於二噁英的基本資料和毒性我就不再贅述了，詳細可以參閱 Dr K Kwong 所寫。我是兒科醫生，所以我參閱的文獻以二噁英對兒童的影響為主。 翻查 Pubmed，近年關於二噁英與兒童的研究，主要針對於產前後 (perinatal) 經母體接觸二噁英對兒童的影響。 這是因為發展中的胎兒對任何有神經毒性 (neurotoxic) 的物質最為敏感，所以理論上影響最大。 巧合的是，就在今年二月， 香港醫學雜誌 （Hong Kong Medical Journal) 就有一份關於香港兒童長達11年的跟進研究 [1]。 但大部分地區包括最近香港發表的研究都是針對 “background level of dioxin” 的影響，即是一般存在於環境的二噁英。 正常來說濃度不高，對嬰孩發展有短期，但無長期的惡性影響 [1-3]。

但問題是，我們現在是擔心被二噁英高度污染，所以參考越南當地的情況應該較適合。 研究人員發現，在受污染地區的媽媽體內的二噁英，比沒有受污染的地區高三至四倍 [4-5]。 研究發現，母親體內的二噁英含量越高，兒童的多方面發展越受到不利影響。 這包括：認知、語言、大小肌肉、身體協調和平衡、和讀寫能力 [5-8]。簡單來說，母親體內二噁英含量越高，兒童在以上各方面表現越差。 這個惡性影響，在跟進到八歲的小朋友身上依然見得到。 受影響的兒童以男孩為主 [6-9]。而且，有發現受影響兒童社交方面發展較弱，有自閉症譜系障礙的徵狀 [10]。

男孩子比較受母體二噁英的影響，又引伸到二噁英引致內分泌異常的問題。 胎兒會因為母親體內二噁英而影響到睪丸激素（testosterone)的分泌 [11-12]，而此激素的異常會影響胎兒腦部成長 （詳情太複雜，不詳述）。 二噁英亦會影響幼童的甲狀腺功能 [13]。

除了以上，還有兩點我覺得需要留意。 第一， 越南被橙劑 (Agent Orange) 毒害已經是多年前的事，但受污地區的婦女體內二噁英含量依然高。 亦有研究發現當年因為911事件世界貿易中心倒塌時釋出的二噁英污染物，經過十幾年後，當時在附近的兒童，體內二噁英含量依然比一般人明顯地高 [14]。 由此可見二噁英的毒害是可以影響深遠。

第二，絕大部分關於母嬰的研究，研究人員都是測量母乳內的二噁英含量做數據。這是因為二噁英是脂溶性的 (lipophilic)，在母乳的含量和身體積存的份量相約，而母乳是容易最獲得的樣本。 這亦表示，嬰孩會經由母乳繼續攝取二噁英。 世界衛生組織 （WHO）基於研究發現產前二噁英經胎盤對胎兒影響比產後經由母乳吸收影響為大，而且母乳有非常多的其他好處 （詳情請參考衛生署網頁）。 由於母乳餵哺的好處多於壞處，所以繼續建議母乳餵哺[15]。 但我認為婦女需要知道母乳含有二噁英這個事實，然後作決定 （informed choice)。

至於關於二噁英與胎兒先天性異常 （congenital abnormality) 和幼童/青少年的影響，我之後有時間/心機讀完書先再分享。

#香港人
#要平安
#記得去投票

1. Hui LL, Lam HS, Lau EY, NElson EA, Wong TW, Fielding R. Prenatal exposure to dioxins and subsequent neurocognitive and developmental function in Hong Kong Chinese children. Hong Kong Med J 2019 Feb;25 Suppl 3(1):35-39.

2. Koopman-Esseboom C, Weiglas-Kuperus N, Ridder MAJ, eat al. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants’ mental and psychomotor development. Paediatrics 1996;97:700-6

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10. Nishijo M, Pham TT, Nguyen AT, Tran NN, Nakagawa H, Hoang LV, Tran AH, Morikawa Y, Ho MD, Kido T, Nguyen MN, Nguyen HM, Nishijo H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam. Mol Psychiatry 2014 Nov;19(11):1220-6.

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12. Araki A, Mitsui T, Miyashita C, Nakajima T, Naito H, Ito S, et al. (2014) Association between maternal exposure to di (2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido study on environment and children’s health. PLOS ONE 9:e109039 10.1371/journal.pone.0109039

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15. Van den Berg M, Kypke K, Kota A, Tritscher A, Lee SY, Magulova K, Fiedler H, Malisch R. WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding. ARCH Toxicol 2017 jan;91(1):83-96

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journal of the chinese medical association sci 在 Journal of the Chinese Medical Association - Lippincott 的相關結果

Editor-in-Chief: Fa-Yauh Lee; ISSN: 1726-4901; Frequency: Monthly; Ranking: 62/169 in Medicine, general & internal; Impact Factor: 2.743. Subscribe to eTOC ... ... <看更多>

journal of the chinese medical association sci 在 Journal of the Chinese Medical Association 最新影響指數 的相關結果

Journal of the Chinese Medical Association2020-2021最新影響指數是2.743。查看更多期刊影響力排名、趨勢分析、實時預測! ... <看更多>

journal of the chinese medical association sci 在 中華醫學會.臺北[[學會歷史]] 的相關結果

目前SCI與SCIE 的選刊標準是一致的，只是在1997年以前，由於資料儲存媒體容量的限制，ISI 所製作之 ... (2003年更名為Journal of the Chinese Medical Association). ... <看更多>

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#2. Journal of the Chinese Medical Association 最新影響指數

Journal of the Chinese Medical Association2020-2021最新影響指數是2.743。查看更多期刊影響力排名、趨勢分析、實時預測!

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目前SCI與SCIE 的選刊標準是一致的，只是在1997年以前，由於資料儲存媒體容量的限制，ISI 所製作之 ... (2003年更名為Journal of the Chinese Medical Association).

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