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在case-control study analysis這個產品中，有3篇Facebook貼文，粉絲數超過1萬的網紅家醫/職醫_陳崇賢醫師，也在其Facebook貼文中提到， 【家庭醫學】～ 自行車安全帽配戴 和 傷害分析 先講看到的結論，沒興趣的就不用往下念了： 騎自行車配戴安全帽，可以降低頭部外傷、嚴重頭部外傷、臉部外傷的風險；但對於頸部，則沒有明顯的保護效果。 ＊ 接下來就是比較生硬的部分了，大家參考使用 第一篇法國病歷對照研究；在人口160萬的區域，199...

case-control study analysis 在 家醫/職醫_陳崇賢醫師 Facebook 的最佳貼文

家醫/職醫_陳崇賢醫師 By 家醫/職醫_陳崇賢醫師

2021-03-22 07:30:49 有 112 人按讚
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【家庭醫學】～ 自行車安全帽配戴 和 傷害分析

先講看到的結論，沒興趣的就不用往下念了：

騎自行車配戴安全帽，可以降低頭部外傷、嚴重頭部外傷、臉部外傷的風險；但對於頸部，則沒有明顯的保護效果。

＊ 接下來就是比較生硬的部分了，大家參考使用

第一篇法國病歷對照研究；在人口160萬的區域，1998-2008年，共收錄13797位受傷自行車騎士。

發現有戴安全帽，對於頭部和臉部有明顯的保護效果，更可以明顯減少「嚴重」頭部外傷的風險。但對於頸部沒有明確保護效果（odd ratio 95% 信賴區間有包含1）

第二篇是2017年的系統性回顧與統合分析，納入40篇研究，一共64000多名受傷的自行車騎士。

結論和前面那篇差不多，戴安全帽，對於頭部及臉部外傷都有保護的效果，特別是「嚴重」頭部外傷。但頸部外傷的勝算比95%信賴區間一樣有包含1，所以沒有明確保護的效果。

〖結語〗

騎自行車，戴個安全帽吧！有戴有保𧙗⋯⋯

我決定之後騎UBIKE也要自備安全帽了，看完不禁冷汗直流。

〖參考文獻〗

Amoros E, Chiron M, Martin J, et alBicycle helmet wearing and the risk of head, face, and neck injury: a French case–control study based on a road trauma registryInjury Prevention 2012;18:27-32.
http://dx.doi.org/10.1136/ip.2011.031815

Jake Olivier, Prudence Creighton, Bicycle injuries and helmet use: a systematic review and meta-analysis, International Journal of Epidemiology, Volume 46, Issue 1, February 2017, Pages 278–292.
https://doi.org/10.1093/ije/dyw153

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case-control study analysis 在 調皮女醫皮膚專科林昀萱醫師 Facebook 的最讚貼文

調皮女醫皮膚專科林昀萱醫師 By 調皮女醫皮膚專科林昀萱醫師

2020-06-02 12:08:19 有 30 人按讚
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酒糟是慢性皮膚發炎疾病，最近有不少文獻探討酒糟跟心血管、消化道、神經系統、自體免疫疾病，還有精神問題有關，甚至有研究認為酒糟越嚴重，跟那些系統性疾病的關聯性越大，但目前仍未有定論。

2015年台灣研究指出，跟酒糟病人顯著有關的心血管問題是血脂異常、冠狀動脈心臟病跟高血壓。去除高血壓、血脂異常、糖尿病因素後，發現冠心症是獨立跟酒糟相關的疾病，而且男性的酒糟患者比女性患者有更高機率合併這些系統性疾病。

後來在一個大規模的研究中發現，最常見跟酒糟有關的問題是憂鬱，再來依序為高血壓、心血管疾病、焦慮症、血脂異常、糖尿病、偏頭痛、類風濕性關節炎、幽門桿菌、潰瘍性結腸炎等等。至於精神問題中的憂慮跟焦慮在酒糟病人最常見，推論可能跟有同樣的發炎機轉有關。心血管疾病中，則以冠狀動脈心臟病跟酒糟病人最為相關，因此酒糟被認為是冠心症的獨立危險因子。然而，腸胃道疾病以目前的資料無法確切證實關聯性。

今年最新發表的一個統合性研究指出，在50442位酒糟病人中，有較高機率有血脂異常還有高血壓的情形，但並未發現跟缺血性心臟病、中風和糖尿病的關聯性。目前認為神經血管調節異常是酒糟跟高血壓的共同機轉，先前也有研究發現某些血壓藥可以舒緩酒糟症狀，或是讓酒糟變嚴重。如果酒糟病人罹患高血壓，首選降壓藥物會是carvedilol和spironolactone ; 降壓藥中的鈣離子阻斷劑會讓血管擴張，酒糟患者不宜使用。此外，酒糟病人的慢性發炎反應可能和血脂異常有關，因此有學者強烈建議若是酒糟病人同時有高血脂問題，首選藥物是statin類的藥，因為除了降血脂外，還有抗發炎的功效 ; 然而statin類的藥可否改善酒糟病人的皮膚症狀則有待更多研究。

那酒糟是癌症的危險因子嗎？西方國家的學者認為酒糟跟某些癌症的致病機轉有關，例如：非黑色素細胞癌的皮膚癌、甲狀腺癌、乳癌和肝癌，但以台灣今年發表的研究結果(65526位酒糟病人)看來，似乎沒找到酒糟跟特定癌症的相關性，或許跟不同種族的基因變異性有關。

整合以上文獻，台灣的酒糟患者在血壓、血脂和冠狀動脈心臟病方面似乎有多加注意的必要，當然其他系統問題也不能忽略。總之，美麗不只有外在的皮相，內在的健康也要多注意喔！

Ref :

1. Is rosacea a risk factor for cancer: A population-based cohort study in Taiwan. Dermatol Sin 2020;38:15-21.

2. Association Between Rosacea and Cardiometabolic Disease: A Systematic Review and Meta-Analysis. J Am Acad Dermatol. 2020 Apr 28;S0190-9622(20)30729-5.

3. Comorbidities in Rosacea: A Systematic Review and Update. J Am Acad Dermatol. 2018 Apr;78(4):786-792.e8.

4. Rosacea Is Associated With Chronic Systemic Diseases in a Skin Severity-Dependent Manner: Results of a Case-Control Study. J Am Acad Dermatol. 2015 Oct;73(4):604-8.

5. Cardiovascular Comorbidities in Patients With Rosacea: A Nationwide Case-Control Study From Taiwan. J Am Acad Dermatol. 2015 Aug;73(2):249-54

#酒糟

#共病症

#高血壓

#血脂異常

#冠狀動脈心臟病

#林政賢皮膚科

#從名畫看皮膚科

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case-control study analysis 在 中央研究院 Academia Sinica Facebook 的最佳解答

中央研究院 Academia Sinica By 中央研究院 Academia Sinica

2019-08-16 21:20:40 有 818 人按讚
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#戒手搖飲又多了一個理由
　　
　　
#注意力缺陷過動症（ADHD）的孩子易衝動、不專心，而這可能與 #飲食型態 有關。

本院生物醫學科學研究所特聘研究員潘文涵表示，在臺灣，每100個孩子約有五到七人罹患過動症，這個疾病致病原因複雜，過去被認為與遺傳、腦傷、神經傳導物質分泌異常、母親懷孕期間喝酒用藥、家庭因素等都有關連。
　　
🔴過動症跟貧血、過敏、血清素不足有關

研究團隊與臺灣大學、長庚大學、臺北醫學大學團隊合作，從大臺北地區31所小學中招募216名ADHD病童，以及年齡、身高體重等條件相似的216名非病童，進行病例對照研究：檢視他們的過敏現象、飲食型態與血液檢驗值的差異，並估算危險因子與疾病風險。

結果發現過動症4個臨床風險因子，包括貧血、血清素偏低、過敏指標之嗜酸性粒細胞與免疫球蛋白較高。這些因子生化異常愈多，過動症風險愈高。具有愈多過敏症狀(鼻炎、濕疹、氣喘)者，與過動症的共病風險也提高。
　　
🔴過動兒營養食物攝取不足

研究團隊進一步分析過動孩子與其他孩子的飲食型態發現，過動孩子吃的食物較不營養，大多是高油、高糖食物，像是含糖飲料、甜食、點心麵等。🙅‍♂🙅‍♀

✏這份研究更首度發現，常用於含糖飲料、加工食品的 #無機磷酸鹽，與過動症的發生有關。

#是不是該戒手搖飲了 #此時不戒更待何時
　　
🔴ADHD的孩子應該怎麼吃？🥦🍎🥛🍠🍋

潘文涵建議過動兒的父母，讓孩子多食用抗發炎且營養素豐富的飲食，如：蔬菜、水果、全榖類、核果、優質蛋白質食物，避免燒烤、油炸食物、甜食等，有助於過敏甚或ADHD的控制。同時也瞭解孩子是否具有過敏體質及貧血問題，重視這些共病並尋求醫學處置。

新聞稿全文：
https://www.sinica.edu.tw/ch/news/6316
　　
------
　　
✏論文發表：去(107)年7月刊登於《科學報告》(Scientific Reports)以及今(108)年5月刊登於《臨床醫學雜誌》(Journal of Clinical Medicine)。

👍研究團隊：本院生醫所潘文涵特聘研究員和葉文婷、中華醫事科技大學符明伶副教授、長庚大學徐榮隆教授和王亮人教授、臺北醫學大學黃士懿教授和楊惠婷副教授、臺灣大學江伯倫教授、陳為堅教授、和楊曜旭教授。

✅論文全文 :
(1) Attention deficit-hyperactivity disorder is associated with allergic symptoms and low levels of hemoglobin and serotonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035203/

(2) Dietary Profiles, Nutritional Biochemistry Status, and Attention-Deficit/Hyperactivity Disorder: Path Analysis for a Case-Control Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6577382/

------
　　
This study is one of very few to examine the relationship between attention deficit hyperactivity disorder (ADHD) and allergies, in combination with indicators of inflammation and immune responses, and to explore the potential inter-relationships among diet, nutritional biochemistry, and ADHD.

ADHD appears to be becoming more prevalent in children and it can have substantial impacts on children and their families. The work of Dr Wen-Harn Pan and colleague at Academia Sinica, National Taiwan University, Chang-Kung Medical Center, and Chung Hua University of Medical Technology explored comorbidities, biomarkers, and dietary and nutritional biochemistry profiles associated with ADHD with the ultimate aim to understand its complex etiology and improve diagnosis, prevention and management.
　　
📍Press Release：https://www.sinica.edu.tw/en/news/6316
　　
------
　　
媒體報導：
【自由時報】過敏、貧血、血清素偏低 罹過動症機率高6～7倍
https://news.ltn.com.tw/news/life/paper/1310388

【中國時報】喝糖飲吃零食 學童易患過動
https://www.chinatimes.com/realtimen…/20190813001972-260405…

【公共電視】中研院：過敏貧血和飲食不當恐增過動症風險
https://www.youtube.com/watch?v=FdxUqzmEH_U

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Rapid Epidemiological Analysis of Comorbidities and Treatments as risk factors for COVID-19 in Scotland (REACT-SCOT): A population-based ...

#48. Design, Conduct, and Analysis of Case Control Studies

Analysis. • General approach ... Case series, case study, personal opinion ... Case Control Study Design. Exposed. Not Exposed. Disease. Cases. Exposed.

#49. 生物統計學-流行病學的研究設計類型,基礎醫學教室 - 高點醫護網

流行病學的研究設計類型包括個案報告(case report)、病例分析(case analysis)、現況調查(cross section study)、病例對照研究(case control study)、對列研究(cohort ...

#50. Case-Cohort Studies vs Nested Case-Control Studies

Some of them such as nested case-control and case-cohort study designs are ... Addendum to methods of cohort analysis: Appraisal by application.

#51. Case control & cohort study - SlideShare

The final step is Analysis: Exposure rate among cases and controls to suspected factors. Estimation of the Disease risk associated with exposure (Odds ...

#52. Case-control and Cohort studies: A brief overview - Students 4 ...

Case -controls can provide fast results and they are cheaper to perform than most other studies. The fact that the analysis is retrospective, ...

#53. CODING MANUAL FOR CASE-CONTROL STUDIES

CODING MANUAL FOR CASE-CONTROL STUDIES ... 1) Comparability of Cases and Controls on the Basis of the Design or Analysis ... adjusted for in the analysis.

#54. Data analysis of Case-Control study using SPSS || Odds Ratio

#55. Case-control Study - methods@manchester

A case-control study is a type of observational study design that is often used in epidemiology. Two groups of people are compared; ...

#56. Automating the Selection of Controls in Case-Control Studies

These controls can then be matched with cases according to a characteristic(s), to ensure the two groups are comparable for further analysis. However, this ...

#57. Nested Case-Control Study Case-Cohort Study

Collect and analyze data for only selected and appropriate number of samples – case-control. Establish study population follow cohort design.

#58. Case-Control Study - SAGE Research Methods

Case -control studies measure the association between the exposure to particular risk factors and the occurrence of a specific disease.

#59. Case-Control Studies - Cambridge University Press

Cambridge Core - Epidemiology Public Health and Medical Statistics - Case-Control Studies.

#60. A case-control study of regular aspirin use and coronary deaths.

D. SUMMARY Information was collected for a large number of coronary risk factors on a series of 568 married, white men, aged 30 ...

#61. Matching in a case control study in practice - Neal D ...

Conceptually the point of matching in case control studies is a pretty ... analysis) that match the case on one or more characteristics, ...

#62. Prospective, Retrospective, Case-control, Cohort Studies

An explanation of different epidemiological study designs in respect of: retrospective; prospective; case-control; and cohort.

#63. Longitudinal/cohort and case-control studies - Virtual ...

Case -control studies permit the identification of risk factors for disease and usually requires a much smaller sample size than cohort studies.

#64. CGEN: An R package for analysis of case-control studies in ...

Description This is a package for analysis of case-control data in genetic epidemiology. It provides a set of statistical methods for evaluating gene- ...

#65. Nested case-control study in a serological survey to evaluate ...

cruzi antibodies by IHA and IFA using the same diagnostic criteria adopted for cases and controls. Statistical analysis. Cases and matched con- trols were ...

#66. Levels of evidence and your therapeutic study - Arthroscopy ...

The case-control study also involves two groups: cases (subjects with a disease ... Controls are then matched to cases, allowing researchers to analyze past ...

#67. A Test-Negative Design with Additional Population Controls C...

Test-negative case–control studies 4–9 are based on persons who undergo testing because they ... The data can be analyzed like any other case–control study, ...

#68. Protocol for case-control studies to measure influenza vaccine ...

The collected variables, their definition, and the plan of analysis were revised based on the results of the pilot studies 2008-09, the recommendations of a ...

#69. Critical Appraisal Tools for Case Control Studies - LibGuides

Case Control study design simply compares a sample population with certain conditions or characteristics and compares them with a sample ...

#70. Meta-analysis of using both cohort and case control study

A relative risk of less than “1” provides the evidence for a defensive outcome of the exposure (the incidence rate of disease among exposed is ...

#71. Analysis of case control studies - Google Sites

Deciding what analysis to use depends on the type of case control study completed and the number of exposure variables of interest.

#72. Case-control Studies: An Overview - Coursera

Video created by Imperial College London for the course "Study Designs in Epidemiology". This module focuses on case-control studies, which is one of the ...

#73. osDesign: An R Package for the Analysis, Evaluation, and ...

In this context,. Page 2. 2. osDesign: Two-Phase and Case-Control Studies in R the design stratifies the population jointly on the outcome and ...

#74. Methodology Checklist 4: Case-control studies

Is the paper really a case-control study? ... 1.10, The main potential confounders are identified and taken into account in the design and analysis. Yes £.

#75. Case control study - Institute for Work & Health

Case control studies start with an outcome (such as a disease) and work backwards to find exposures that may be linked to it.

#76. Methodology Checklist 4: Case-control studies

or controls may differ from other members of the source population in some significant way. A well conducted case- control study will look at ...

#77. Selection of Controls in Case-Control Studies - McGill University

Reduced flexibility in analysis. Stratified or matched analyses can be considered, even when there was no matching or stratification in the ...

#78. case–control studies | The social care guidance manual - NICE

Appendix E Methodology checklist: case–control studies ... confounders are identified and taken into account in the design and analysis.

#79. 5. Study design - ENCePP

Observational Studies: Cohort and Case-Control Studies (Plast Reconstr Surg. ... Considerations for pharmacoepidemiological analyses in the SARS-CoV-2 ...

#80. Calculating Measures of Association Case-control studies The ...

The odds ratio is the measure of association for a case-control study. ... higher the odds of exposure is among cases of a disease compared with controls.

#81. A Simulation Study of Relative Efficiency and Bias in the ...

Purpose: The nested case–control study design, in which a fixed number of controls are matched to each case, is often used to analyze ...

#82. A Case–Control Study of Screening Sigmoidoscopy and ...

Abstract Background The efficacy of sigmoidoscopic screening in reducing mortality from colorectal cancer remains uncertain.

#83. Study Designs - EAL - Evidence Analysis Library

Case Control Study A study which involves identifying patients who have the outcome of interest (cases) and matching them with individuals who have similar ...

#84. Levels of Evidence - Elsevier

analysis. LEVEL. III. Case-control study. Retrospective comparative study. Case-control study. Study of nonconsecutive patients and/or without.

#85. Two-phase designs in epidemiology

This document explains how to analyse case–cohort and two-phase case–control studies with ... full sampling to compare with the two-phase analyses.

#86. Epidemiologic Study Designs - Johns Hopkins Medicine

Case -Control Study. Descriptive Study. Clinical Observation ... Challenges in Case-Control Studies ... controlled for in the study design or analysis?

#87. Epidemiology - Knowledge @ AMBOSS

case -control studies ... randomized controlled trials ... See also “Interpreting medical evidence,” “Statistical analysis of data,” and ...

#88. 證據等級 - 長庚醫院

高品質之整合分析（meta analysis），系統性文獻回顧（systematic reviews）之隨機 ... 經過病例對照研究（case-control study）或世代研究（cohort study）之高品質 ...

#89. Case-Control Studies: Statistical Analysis - ppt video online ...

Rothman claims, “Properly carried out, case-control studies provide information that mirrors what could be learned from a cohort study, ...

#90. Levels of Evidence - Evidence Based Practice Toolkit

Evidence from well-designed case-control or cohort studies. Level V ... Randomized controlled trial (RCT), meta-analysis. Also: cohort study ...

#91. Case-crossover design in air pollution epidemiology

As in a matched case-control study, the inference is based on a comparison of ... In the 1990s, Poisson regression analysis and sophisticated modelling ...

#92. Cohort, Case-Control, Meta-Analysis & Cross-sectional Study ...

Meta-analysis of multiple Randomized Trials (Highest Validity); Randomized Trial; Prospective Cohort Studies; Case Control Studies or Retrospective Cohort ...

#93. Case-control study | Osmosis

Case -control studies are a type of study design that compares the history of two groups of people - those that have a certain outcome, called cases, ...

#94. COVID-19 vaccine information - Australian Government ...

An interim analysis at 2 months after dose 2 reported vaccine efficacy of ... A test-negative case–control study was conducted in the United ...

#95. Factors associated for COVID19 Severity | IJGM - Dove ...

Methods: A case–control study was implemented among patients admitted to ... Results from multivariable logistic regression analysis were ...

#96. Test-Retest Reliability of Ultrasonographic ... - MDPI

An observational case-control study with individuals (18–60 years aged) who underwent surgery for anterior cruciate ligament through knee ...

#97. COVID-19 vaccine surveillance report - week 12 - GOV.UK

Vaccination status in cases, deaths and hospitalisations . ... Omicron variant has been estimated using a test-negative case control study.

#98. Encyclopedia of Quantitative Risk Analysis and Assessment

On the need for the rare disease assumption in case-control studies, American Journal of Epidemiology 116, 547–553. [20] Cornfield, J. (1951).