關於 side effect of hormone therapy ，我們在網路上蒐集到這些相關的討論、資訊與評價

巧克力囊腫，除了副作用很多的Gn-RHa therapy（柳普林）之外
，還有更好的選擇Pycongnol碧容健—毫無副作用！

Pine Bark Significantly Reduces Endometriosis, New Study Finds
Hethir Rodriguez C.H., C.M.T.Hethir Rodriguez C.H., C.M.T.

The Study:
Pine Bark Shown to Be Helpful for EndometriosisThere’s promising hope for women who suffer from endometriosis, one of the most common causes of infertility and pelvic pain. A new study to be published in an upcoming edition of the Journal of Reproductive Medicine reveals that Pycnogenol (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, significantly reduces symptoms of endometriosis by 33 percent.

Pycnogenol which holds a patent for reducing PMS/menstrual pain and discomfort, was chosen for this study because other endometriosis treatments can have unwanted side effects. “The cause of endometriosis is unknown and treatment to fully cure endometriosis has yet to be developed,” said Dr. Takafumi Kohama, a lead researcher of the study. “Common hormone treatments such as gonadotropin-releasing hormone agents (Gn-RHa) may likely restrict women from becoming pregnant during treatment. Danazol, another hormone treatment, produces side effects such as ovarian deficiency, osteoporosis and obesity. Our results convey Pycnogenol as an extremely effective natural treatment without dangerous side effects,” he said.

Patients who supplemented with Pycnogenol took 30 mg capsules orally twice daily for 48 weeks immediately after morning and evening meals. Patients who received the Gn-RHa therapy received injected leuprorelin acetate depot, 3.75 mg intracutaneously, six times every four weeks for 24 weeks. (Leuprorelin treatment completely blocks estrogen in the body and must be discontinued after 24 weeks because of side effects).

Both treatment groups showed no differences at start of treatment and reported severe pain, pelvic tenderness and pelvic indurations. After four weeks, Pycnogenol slowly but steadily reduced all symptoms from severe to moderate. Treatment with Gn-RHa reduced the scores more efficiently but after 24 weeks post-treatment a relapse of symptoms occurred.

There have been significant studies with Pycnogenol revealing treatment efficacy of common problems associated with menstruation, such as dysmenorrhea, menstrual pain and endometriosis. Research has shown a reduction in abdominal pain due to endometriosis. Studies have shown a clear improvement in terms of reduction of menstrual cramps and pain in 73% of women following administration of 30 mg Pycnogenol day for one month, in addition to those with endometriosis. Abdominal pain due to endometriosis was reduced in 80% of the patients and cramps disappeared in 77% of the women taking Pycnogenol according to a study published in the European Bulletin of Drug Research.

About Pycnogenol

Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 35 years and has more than 220 published studies and review articles ensuring safety and efficacy as an ingredient.

Reference: Kohama, T., Herai, K., & Inoue, M. (2007). Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate. Journal of Reproductive Medicine – Chicago-, 52(8), 703.

CJC-1295 Latest Research Benefits And Side Effects.

The tetrasubstituted peptide hormone called CJC-1295 has 30 amino acids in it and functions like GHRH, but with much better results overall. First of all, its potential in increasing the effects that growth hormones and IGF-I haveCJC-1295 and stimulating them is huge. Plus, those effects increase without having to change the prolactin levels in any way. In turn, this results in better protein synthesis, more fat loss and more muscle growth.

The reason why CJC-1295 seems to work better compared to GHRH or rHGH is because of its ability to work with album in order to produce a better half-life and a better form of therapy. This form of technology is still quite new. In a nutshell, though it attaches certain reactive groups onto peptides to make them react to nucleophilic entities in the blood and make them more stable. It can also serve as a form of protection from GHRH amino acids, which normally degrade enzymes.

After attaching itself to albumin, CJC-1295 gets a better half-life and better bioavailability, in general. Thanks to the effectiveness of bioconjugation, very little of CJC-1295 will fail to react. Most of it will actually stabilize after using subQ , making it well worth the investment in the end.

During the 2000s, clinical studies were finally done for CJC-1295 and it was shown that its primary goal was to deal with visceral fat deposits in order to bring about more fat loss and that it was successful therein.

For stability, CJC-1295 relies on substitutions of Gin, Ala, D-Ala and Leu, which are also in charge of stopping the DPP-IV cleavage and the methionine oxidation, as well as improving the bioactivity and half-life of CJC-1295‘s from seven minutes to an entire week.

Since this half-life is much longer, researchers are able to use the peptide every week to reap the results that they want. CJC-1295 has already gone through various experiments to test its effectiveness. After more than 6 days, an increase in plasma GH concentration has been seen. After 11 days, on the other hand, an increase in IGF-1 concentration has also been seen. This makes the average half-life stand at up to 8.1 days, staying above the overall baseline even after a month without any unwanted side effects.

CJC-1295 can also help with deep sleep, which is in charge of muscle growth and memory retention. Although deep sleep is known to diminish with time, this peptide’s side effect ratio actually surpasses that of any other ones out there, thus making it the best choice for post cycle therapy overall.