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#1. OS vs. PFS: What You Need to Know - Metastatic Trial Talk
Clinical trials are set up to look at specific outcomes. In some trials, researchers set out to look at progression-free survival (PFS), ...
#2. 以無惡化存活時間(PFS)評估抗癌藥物療效之考量 - 財團法人 ...
以「無惡化存活時間(Progression Free Survival, PFS)」為主要療效指標的詴驗有 ... 證據顯示PFS 可以作為「整體存活(Overall Survival, OS」的替代性療效指標，且.
#3. Progression-free survival as a surrogate for overall ... - Nature
Progression -free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate ...
#4. Definition of progression-free survival - NCI Dictionary of ...
progression -free survival ... The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does ...
#5. Progression-free survival - Wikipedia
Progression -free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease ...
#6. What do clinical trial results mean? | Cancer Research UK
Progression free survival (PFS), The time between treatment aimed at shrinking or controlling cancer, and signs that it has started to grow ...
#7. Assessment of Progression-Free Survival as ... - JAMA Network
Importance The Gynecologic Cancer InterGroup (GCIG) recommended that progression-free survival (PFS) can serve as a primary end point instead of ...
#8. Progression-Free Survival: Meaningful or Simply Measurable?
Schematic of potential progression-free survival (PFS) and overall survival (OS) results in trial of arm 1 (experimental) versus arm 2 ...
#9. What is the difference between OS and PFS? - ResearchGate
Overall survival is referred to mean duration of survival after diseases is diagnosed or treated. It did not account for disease progression. While progression ...
#10. Interpreting progression-free survival and overall survival data ...
Background: Oncology trials often report data on progression-free survival (PFS) or overall survival (OS), but such endpoints are prone to be less sensitive ...
#11. Patient Centered Approach: What Do Efficacy Endpoints Mean?
Overall Survival (OS). – Progression Free Survival (PFS). – Overall Response Rate (ORR). – Disease Free Survival (DFS).
#12. Progression-free survival is a suboptimal ... - Science Direct
PFS primary end-point (PEP) trials more likely to succeed (67%) versus OS PEP (33%). •. PEP success associated with molecular profile restriction and single ...
#13. Progression-Free Survival: What Does It Mean for ...
There was no direct evidence demonstrating that knowing PFS status impacts patient anxiety, depression, or psychological well-being. KQ2 sought to determine an ...
#14. Progression-Free Survival as a Surrogate ... - Value in Health
In a previous study, the quantitative relationship between progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM) was assessed.
#15. Detecting an Overall Survival Benefit that Is Derived From ...
Whether progression-free survival (PFS) or overall survival (OS) is the ... We compared the sample sizes required for PFS vs OS for various ...
#16. Systematic Review and Meta-Analysis of Correlation of ...
Systematic Review and Meta-Analysis of Correlation of Progression-Free Survival-2 and Overall Survival in Solid Tumors.
#17. What does "Overall Survival" and "Progression ... - YouTube
What does "Overall Survival" and "Progression Free Survival" mean? ... How do results from clinical trials tell if a treatment works and help ...
#18. Exploration of modified progression-free survival as a novel ...
A status of 1 indicates occurrence of a PFS or mPFS event. In this study of reconstructed and original individual patient-level data (IPD) from ICI trials, we ...
#19. Relationship Between Progression‐Free Survival, Objective ...
PD-1/PD-L1 immune checkpoint blockade (ICB) has improved overall survival (OS) in solid tumor trials; however, parallel improvements in ...
#20. PFS-OS - NICE Decision Support Unit
Progression -free survival (PFS), time-to-progression (TTP) and overall survival (OS) are commonly used endpoints in randomised controlled trials (RCTs) and ...
#21. Progression-free survival as a surrogate endpoint of overall ...
Progression -free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer Giuseppe Cicero,1 ...
#22. What Survival Rate Really Means With Cancer - Verywell Health
3 This is also sometimes referred to as "relapse-free survival." Note that overall survival includes both those who are surviving without any ...
#23. Understanding Statistics Used to Guide Prognosis and ...
The “overall survival rate” is when it includes all people with a specific ... Disease-free survival (DFS) statistics and progression-free survival (PFS) ...
#24. On-line Supplemental Appendix Protocol Definitions ...
Progression -free survival (PFS) was measured from the date of randomization to ... Best overall response was measured by RECIST from randomization to PD.
#25. Surrogates - PFS vs OS - Office of Health Economics
... from Progression Free Survival to Overall Survival in Oncology. ... The increase in the length of overall survival (OS) is the 'gold ...
#26. Clinical Trial Endpoints - OncologyPRO
Overall Response Rate (ORR) or reduction of a tumour marker (e.g. PSA response rate). ◇. Progression-free survival (PFS) or percent without progression at ...
#27. Clinical Significance of the Relationship between Progression ...
The effects of first-line chemotherapy on overall survival (OS) might be ... between Progression-Free Survival or Postprogression Survival and Overall ...
#28. Progression-free survival as a surrogate ... - SAGE Journals
Background:Progression-free survival (PFS) has been adopted as the primary endpoint in many randomized controlled trials, ...
#29. The Progression-Free Survival to Overall Survival Connection ...
If a therapy in castrate-resistant prostate cancer (CRPC) shows an improvement in progression-free survival, but not overall survival, ...
#30. OA 14.02 Rethinking Progression-Free Survival (PFS) as a ...
OA 14.02 Rethinking Progression-Free Survival (PFS) as a Clinical Trials Surrogate for Overall Survival (OS). D. Stewart.
#31. Hepatic Progression-free and Overall Survival After Regional...
All patients above 18 years of age who presented for treatment of cutaneous or uveal melanoma with metastatic disease to the liver regardless of age or status ...
#32. Noninferior Progression-Free Survival and Reduced ...
Randomization was stratified by del(17)(p13.1) status, Eastern Cooperative Oncology Group (ECOG) performance status score (2 vs ≤ 1), and ...
#33. Results: The 3-year actuarial overall survival, progression-free ...
Results: The 3-year actuarial overall survival, progression-free survival (PFS), and local control rate in all 84 patients after radiotherapy was 67%, 61%, ...
#34. Progression Free Survival Or Overall Survival Reconciling An ...
Building clinical trial designs that optimize across both progression free survival (PFS) and overall survival (OS) has historically proven.
#35. Statistical considerations and endpoints for clinical lung cancer studies
Statistical considerations and endpoints for clinical lung cancer studies: can progression free survival (PFS) substitute overall survival (OS) as a valid ...
#36. Understanding the endpoints in oncology: overall survival ...
Overall Survival versus Survival Rate: The term overall survival ... Table 2: Comparison of Overall Survival and Progression Free Survival ...
#37. Clinical Trial Endpoints in Cancer Research: Four Terms You ...
Overall survival, or OS, measures how long patients, ... for measuring the effectiveness of cancer drugs is progression-free survival, ...
#38. Pembrolizumab versus Chemotherapy for PD-L1–Positive ...
Secondary end points were overall survival, objective response rate, and safety. Results. Median progression-free survival was 10.3 months (95% ...
#39. Understanding Overall Survival in Metastatic Breast Cancer
Learn what overall survivals means for women with HR+, HER2- metastatic breast cancer and how it is different from progression-free survival.
#40. Progression-free survival as a surrogate endpoint in advanced ...
In oncology clinical trials, overall survival (OS) is considered the gold standard outcome measure. In phase III trials for neuroendocrine neoplasms (NENs), ...
#41. PFS as a surrogate for OS in Oncology 26-02-2018AF.pdf
Moreover, the use of IPD to assess surrogacy should increase. Keywords: cancer, surrogate endpoints, overall survival (OS), progression-free survival. (PFS), ...
#42. PFS and Overall Survival in Randomized Cancer Therapy Trials
The Waning Relationship Between Progression-Free Survival and Overall Survival ... if the post-treatment survival was 2 months vs 24 months, respectively.
#43. Progression Free Survival (PFS), and Event Free Survival ...
Progression Free Survival (PFS), and Event Free Survival (EFS) from a Global Randomized Phase 3 Study of Guadecitabine (G) Vs Treatment Choice ( ...
#44. Cancer Trials: Is Progression-Free Survival Enough?
A new study questions the use of progression-free survival as a surrogate endpoint in cancer clinical trials after finding it overlooks ...
#45. Surrogate endpoints for overall survival in chemotherapy and ...
We investigated disease-free survival (DFS) or progression-free survival ... Number of patients (trials), DFS or PFS vs overall survival ...
#46. 癌症臨床試驗的常用終點 - 呼吸希望
無病存活期(Disease-free survival, DFS)：這是指治療與疾病復發之間的時間。 ... 整體存活率(Overall survival, OS)：這是指患者從治療開始直至因任何原因而死亡之間 ...
#47. AstraZeneca presents superior progression-free survival for ...
The PFS improvement with Imfinzi was observed across all pre-specified subgroups, including PD-L1 expression status. Patients receiving Imfinzi ...
#48. Long-term overall survival and progression-free survival in ...
Long-term overall survival and progression-free survival in idiopathic pulmonary fibrosis treated by pirfenidone or nintedanib or their switch. Real world data ...
#49. Primary end points of clinical trials - overall survival versus ...
This roundtable discussion looks at the advantages and disadvantages of overall survival and progression free survival as primary end points of clinical ...
#50. Are progression-free and disease-free survival the new gold ...
Overall survival is the gold standard and primary outcome of interest for cancer clinical trials. It is an 'appropriate measure' for ...
#51. Secondary malignant neoplasms, progression-free survival ...
For progression-free and overall survival, hazard ratios derived from each ... RT at 20 Gy; more vs. fewer cycles of the same chemotherapy ...
#52. challenges and methodologies in using progression free ...
OS, overall survival; PFS, progression-free survival; PhD, ... status at progression, (iv) PFS of first line chemotherapy, (v) tumor stage ...
#53. Cancers | Free Full-Text - MDPI
Progression -Free Survival and Overall Survival in Patients with Advanced HER2-Positive Breast Cancer Treated with Trastuzumab Emtansine (T-DM1) after Previous ...
#54. Combining tumour response and progression free survival as ...
Progression free survival (PFS) and tumour response (TR) have been investigated as surrogate endpoints for overall survival (OS) in advanced ...
#55. Progression-free survival is a suboptimal predictor for overall ...
PFS trials were more likely to restrict patient eligibility by using molecular criteria (15.1% versus 4.4%, p = 0.005) use targeted therapy (80.1% versus 67.5%, ...
#56. HSR20-095: Progression-Free Survival, Overall ... - JNCCN
HSR20-095: Progression-Free Survival, Overall Survival, and Tumor Response for Patients Diagnosed With Small Cell Lung Cancer Who Received First ...
#57. Magnitude of the Benefit of Progression-Free Survival ... - PLOS
... progression-free survival-hazard ratios (PFS-HR) (mean, 0.40 vs. ... The odds ratio for overall response was higher in trials with ...
#58. 癌症病人預後的評估工具簡介：存活期、反應率
例如中位存活期（median overall survival） 11.5個月，代表約有一半的病人存活 ... 疾病無惡化存活期（progression-free survival）是指從治療後開始觀察直到病人疾病 ...
#59. Meta-analysis of the association between progression-free ...
PURPOSE: The validity of progression-free survival (PFS) as a surrogate endpoint for overall survival (OS) in metastatic colorectal cancer (mCRC) trials has ...
#60. Measuring patient outcomes in clinical trials - Roche
Historically, we have measured the efficacy of cancer treatments in clinical trials in terms of overall survival (OS) and progression-free survival (PFS).
#61. Lung Cancer Progression-free survival and overall survival in ...
For instance, in a randomized controlled trial of erlotinib (investigational arm) versus placebo (reference arm), if patients allocated to the reference arm ...
#62. Retrospective Analysis Of Progression Free Survival And ...
Retrospective Analysis Of Progression Free Survival And Overall Survival In A National Cohort Of Patients With Metastatic Renal Cell Carcinoma Treated In ...
#63. Oropharynx Cancer Progression Free Survival Calculator
Predicted 2-year Progression Free Survival: Predicted 5-year Progression Free Survival:.
#64. Real life patterns of care and progression free survival in ...
Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional ...
#65. Progression-Free Survival and Patient Quality of Life Are Not ...
CancerTherapyAdvisor.com is a free online resource that offers oncology healthcare professionals a comprehensive knowledge base of practical ...
#66. The Significance of Progression-Free Survival as a Clinical ...
Here we discuss the relative merits of 2 survival end points-overall survival (OS) and progression-free survival (PFS)-and the value of PFS ...
#67. Disease-Free Interval and Overall Survival in HER2+ BC
There was a 26% rate of brain metastasis in that group vs 15% in patients relapsing more than a year. But because you don't know who's going to ...
#68. Apatinib therapy improves progression-free survival in iodine ...
Apatinib therapy improves progression-free survival in ... and the overall 12-month survival rate was 95.4% vs 79.7% (apatinib vs placebo).
#69. Study Results Champion Keytruda/Chemo as 'New Standard ...
Progression -free survival, which is the time a patient lives before ... overall survival for Keytruda vs placebo was 16.2 months vs 14.7 ...
#70. Elacestrant Shines in EMERALD Trial - Clinical Oncology News
... improvement in progression-free survival versus standard-of-care endocrine ... Overall survival analysis was not mature, but researchers ...
#71. 整體存活率vs 無病存活率overall survival vs disease-free survival
overall survival vs disease-free survival. 在使用存活分析時，通常我們想要知道是事件的存活率是多少? 或是時常聽到五年的 ...
#72. Practice-Changing Data From 2021 Sets Tone for New Year
The median duration of response with censoring at subsequent allogeneic stem cell transplant, relapse-free survival, and overall survival (OS) ...
#73. First-Line Nivolumab/Ipilimumab Yields Durable Survival ...
Moreover, the investigator assessed median intracranial progression-free survival (PFS) was not reached in cohort A, and was 39.3 months per ...
#74. List of drugs in phase 3 clinical trials 2021
Progression -free survival is the amount of time before cancer grows or spreads to ... whether an "early aggressive" therapy approach, versus starting with a ...
#75. Reduced Radiation in Oropharynx Cancer - Medscape
Comparable progression-free survival was observed in ... Overall, these results show that "we could reduce radiation therapy and eliminate ...
#76. Correlation of progression free survival-2 and overall ... - X-MOL
Overall survival (OS) has become the definitive endpoint in oncology clinical trials, but may be difficult to assess due to need for lengthy follow-up, factors ...
#77. Paper: Phase II Study of Venetoclax in Combination with ...
3 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital ... 2 year Overall Survival (OS) and Progression-Free Survival (PFS) (90% ...
#78. NCCN collaborates with Pfizer to advance PARP inhibitors in ...
The National Comprehensive Cancer Network (NCCN) has awarded ... Radiographic progression-free survival is the primary end point of the ...
#79. prostate cancer - MDLinx
Metastasis-free survival did not differ when enzalutamide and ... and progression-free-survival (0·44, 0·36–0·54), vs the control groups.
#80. HER2CLIMB final OS analysis confirms tucatinib HER2 ...
... capecitabine continues to confer an overall survival (OS) benefit in ... showed significantly improved OS and progression-free survival ...
#81. Knight Therapeutics Inc. Announces Approval of Lenvima® in ...
... a statistically significant progression-free survival prolongation ... was proven to be non inferior to sorafenib for overall survival.
#82. Trastuzumab Deruxtecan Type II Variation Application ...
The median progression-free survival (PFS) for patients treated with ... the trastuzumab deruxtecan arm versus the T-DM1 arm (79.7% [n=208; ...
#83. Jobs with Immunomedics, Inc. - BioSpace
Confirmatory Phase 3 ASCENT study met primary endpoint of progression-free survival and key secondary endpoints of overall survival and objective response ...
#84. Antivirals - IDSA
Secondary outcomes included clinical status at day 15 using the ordinal scale. Key findings: Patients who received remdesivir had a median recovery time of 10 ...
#85. Neighborhood Socioeconomic Disadvantage Associated with ...
Major complications, mortality and survival outcomes were compared ... demonstrated worse overall survival and recurrence free survival than ...
#86. Pancreatic Cancer: New Experimental Therapy Moves Forward
The primary endpoint for the trial is overall survival. ... show that both median progression-free survival (iPFS) and overall survival are ...
#87. Relationship between Treatment Effects on Progression-Free ...
Background: Demonstrating improved overall survival (OS) with new multiple myeloma (MM) treatments is becoming difficult because of extended ...
#88. Non-Melanoma Skin Cancer and Cutaneous Melanoma: Surgical ...
vs. investigator's choice chemotherapy for ipilimumab- refractory melanoma patients and ... Progression-free survival was improved in patients assigned to ...
#89. Analysis of published literature on - cloudfront.net
the relationship between patient overall survival and other patient outcomes. (response rate and progression-free survival) in clinical trials of immuno-.
#90. Is Disease-Free Survival a Meaningful Endpoint in NSCLC?
And then they were randomized 1:1 to either atezolizumab, 1200 mg IV every 3 weeks versus best supportive care. So I think that's probably where ...
#91. Get Information on How to Prolong Survival in ... - Provenge
PROVENGE: POWERFUL OVERALL SURVIVAL DATA. IMPACT: PROVENGE extended life for men with mCRPC 1,2. In IMPACT, the double-blind ...
#92. Assessment of Progression-Free Survival as a ... - GCIG
Assessment of Progression-Free Survival as a Surrogate End Point of Overall Survival in First-Line Treatment of Ovarian Cancer: A Systematic ...
#93. Mesothelioma Survival Rates & Statistics by Age, Gender ...
Individual Characteristics and Mesothelioma Survival. Tumor Location; Stage of disease; Mesothelioma cell type; Age at diagnosis and overall ...
#94. 생존 분석 (Survival analysis)
생존 분석 (Survival analysis) Start. BioinformaticsAndMe. #생존분석에 대한 R 분석 예제는 아래 포스팅 참조.
#95. Thomas' Hematopoietic Cell Transplantation
21% and 46% vs. 30%, respectively. ... Overall survival at 3 years increased from 35% to 55%. Median progression-free survival improved from 7 to 19 months.
#96. Radiotherapy in Prostate Cancer: Innovative Techniques and ...
... difference in overall survival, 78% in favor of the combination versus 62 ... distant progression free survival (PFS) from 30.2 to 51.0% (P\0.0001), ...
#97. Survival analysis 1: a gentle introduction into Kaplan-Meier ...
Then what is? Since we have zeros and ones in the status column we can use a logistic regression, right?! Yes! Especially because probability ...
progression-free survival vs overall survival 在 What does "Overall Survival" and "Progression ... - YouTube 的推薦與評價
What does "Overall Survival" and "Progression Free Survival" mean? ... How do results from clinical trials tell if a treatment works and help ... ... <看更多>