Genetics. Heterozygous mutations in MC4R are associated with dominantly inherited obesity and have been reported in obese people from various ethnic groups. ... <看更多>
「mc4r gene」的推薦目錄：
mc4r gene 在 MC4R Gene - Melanocortin 4 Receptor 的相關結果
MC4R (Melanocortin 4 Receptor) is a Protein Coding gene. Diseases associated with MC4R include Body Mass Index Quantitative Trait Locus 20 and Obesity Due To ... ... <看更多>
mc4r gene 在 Gene ResultMc4r melanocortin 4 receptor [ (house mouse)] 的相關結果
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small ... ... <看更多>
mc4r gene 在 Melanocortin 4 receptor 的相關結果
Melanocortin 4 receptor (MC4R) is a melanocortin receptor that in humans is encoded by the MC4R gene. ... It encodes the MC4R protein, a G protein-coupled ... ... <看更多>
mc4r gene 在 Entry - *155541 - MELANOCORTIN 4 RECEPTOR; MC4R 的相關結果
HGNC Approved Gene Symbol: MC4R. Cytogenetic location: 18q21.32 Genomic coordinates (GRCh38): 18:60,371,062-60,372,775 (from NCBI). ... <看更多>
mc4r gene 在 Obesity due to melanocortin 4 receptor deficiency 的相關結果
MC4R is a G protein-coupled receptor involved in the hypothalamic leptin-melanocortin signalling pathway. Activation of the MC4R plays a key role in the ... ... <看更多>
mc4r gene 在 Evaluation of the MC4R gene across eMERGE network ... 的相關結果
The melanocortin-4 receptor (MC4R, OMIM:155541) is a G protein-coupled receptor that is critical in leptin–melanocortin pathway. The protein ... ... <看更多>
mc4r gene 在 MC4R - Melanocortin receptor 4 - Homo sapiens (Human) 的相關結果
Type. ‑‑ Select ‑‑ ID Position(s)
Natural variant VAR_038632 11
Natural variant VAR_010704 30
Natural variant VAR_038633 36 ... <看更多>
mc4r gene 在 Identification of a Rare and Potential Pathogenic MC4R ... 的相關結果
MC4R gene is located on chromosome 18q21.3, spans more than 1.6 kb, and encodes a 332 amino acid protein. This protein is expressed in ... ... <看更多>
mc4r gene 在 Melanocortin 4 Receptor - an overview 的相關結果
The melanocortin-4 receptor (MC4R) is a seven-transmembrane G-protein coupled receptor that is expressed predominantly in the brain and encoded by the MC4R gene ... ... <看更多>
mc4r gene 在 Obesity and the MC4R Gene 的相關結果
Mutations in MC4R are the most common genetic cause of obesity. Many MC4R mutations have been documented. Some reduce gene function, some eliminate function ... ... <看更多>
mc4r gene 在 Melanocortin 4 receptor (MC4R) gene variants in children ... 的相關結果
Melanocortin 4 receptor gene plays an important role in food intake, energy balance, and weight control. The autosomal dominantly inherited ... ... <看更多>
mc4r gene 在 Human Gene MC4R (ENST00000299766.5) from ... 的相關結果
Description: Homo sapiens melanocortin 4 receptor (MC4R), mRNA. (from RefSeq NM_005912) RefSeq Summary (NM_005912): The protein encoded by this gene is a ... ... <看更多>
mc4r gene 在 2021: Gene mutation - MC4R | Avon Longitudinal Study of ... 的相關結果
One of these genes, the Melanocortin 4 Receptor (MC4R), makes a protein that is produced in the brain where it sends signals to our appetite ... ... <看更多>
mc4r gene 在 Clinical Spectrum of Obesity and Mutations in the ... 的相關結果
Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. However, the clinical spectrum and mode of inheritance ... ... <看更多>
mc4r gene 在 Gene: MC4R (ENSG00000166603) - Summary 的相關結果
Gene : MC4R ENSG00000166603 ... Chromosome 18: 60,371,062-60,372,775 reverse strand. ... This gene has 1 transcript (splice variant), 229 orthologues, 18 paralogues ... ... <看更多>
mc4r gene 在 Obesity due to melanocortin 4 receptor (MC4R) deficiency ... 的相關結果
Melanocortin-4 receptor (MC4R) signalling plays a pivotal role in the regulation of body weight and genetic disruption of MC4R causes ... ... <看更多>
mc4r gene 在 MC4R Gene 的相關結果
tissues with high or low expression of MC4R gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles ... ... <看更多>
mc4r gene 在 Mc4r MGI Mouse Gene Detail - melanocortin 4 receptor 的相關結果
Mc4r. Name. melanocortin 4 receptor. Synonyms. Fatboy, Pkcp. Feature Type. protein coding gene. IDs. MGI:99457. NCBI Gene: 17202. Alliance. gene page. ... <看更多>
mc4r gene 在 Association of MC4R (rs17782313) with diabetes and ... 的相關結果
The MC4R gene was associated with BMI and is involved in the regulation of insulin secretion [5, 16]. Loos et al. [5] in a meta-analysis from ... ... <看更多>
mc4r gene 在 MC4R Mutations—Weight before Screening! - Oxford Academic 的相關結果
The MC4R gene has only a single exon and thus is amenable to mutation ... Probands with homozygous MC4R mutations show more severe obesity than their ... ... <看更多>
mc4r gene 在 Functional Characterization of Variants in MC4R Gene ... 的相關結果
Conclusions: We have described, for the first time, two novel human MC4R gene promoter variants found in obese children that resulted in a decrease in basal ... ... <看更多>
mc4r gene 在 Gene MC4R 的相關結果
The MC4R gene codes for melanocortin 4 receptor. The melanocortin pathway controls appetite and eating behaviors [R, R]. Activating MC4R in animals leads to ... ... <看更多>
mc4r gene 在 MC4R Gene Spotlight 的相關結果
MC4R Gene Spotlight ... The Melanocortin 4 Receptor (MC4R) is a receptor found in the hypothalamus and involved in the regulation of satiety, food ... ... <看更多>
mc4r gene 在 MC4R - DNAlysis 的相關結果
Melanocortin-4 Receptor. MC4R T>C. Allele Frequency. The 1000 Genomes Project Database and the genome Aggregation Database (gnomAD) reports ... ... <看更多>
mc4r gene 在 Mc4r (melanocortin 4 receptor) - Rat Genome Database 的相關結果
Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 ... ... <看更多>
mc4r gene 在 MC4R Pathway 的相關結果
The melanocortin-4 receptor (MC4R) pathway is a key component of the central hypothalamic regulation of hunger. The importance of the MC4R pathway's control ... ... <看更多>
mc4r gene 在 MC4R single gene test 的相關結果
MC4R single gene test. Analysis methods. PLUS. Availability. Results in 3-4 weeks. Test code. S01160. CPT Code *. 81403, 81403, 81479. Phenotype. ... <看更多>
mc4r gene 在 Patients with Obesity Caused by Melanocortin-4 Receptor ... 的相關結果
Liraglutide caused a 6% weight loss in patients with MC4R ... quency functional mutations in the melanocortin-4 receptor (MC4R) gene, and. ... <看更多>
mc4r gene 在 Large quantitative effect of melanocortin-4 receptor gene ... 的相關結果
The first mutations in the human MC4R gene were reported in extremely obese probands. Since then, several other studies investigated the association of ... ... <看更多>
mc4r gene 在 The MC4R gene homepage - Global Variome shared LOVD 的相關結果
General information. Gene symbol, MC4R. Gene name, melanocortin 4 receptor. Chromosome, 18. Chromosomal band, q22. Imprinted, Unknown. ... <看更多>
mc4r gene 在 Monogenic Obesity via the MC4R Gene Test 的相關結果
Severe early-onset obesity caused by heterozygous mutations in the melanocortin-4 receptor gene (MC4R) is typically dominantly inherited (Vaisse et al. ... <看更多>
mc4r gene 在 Genetic markers for improved meat characteristics in ... 的相關結果
Genetic markers in the porcine melanocortin-4 receptor (MC4R) gene are disclosed which are associated with favorable meat quality traits including, ... ... <看更多>
mc4r gene 在 Human MC4R; MC4-R Gene in Lentivector, Endotoxin-free ... 的相關結果
Construct Details: Full length human MC4R gene is subcloned into the Lentiviral expression vector pLTC with an upstream CMV promoter and with or without a ... ... <看更多>
mc4r gene 在 Know Your Genes: MC4R “Obesity Gene” 的相關結果
The Melanocortin 4 Receptor gene (MC4R) is associated with the synthesis of MC4R enzyme, a G protein coupled receptor which is found to bind ... ... <看更多>
mc4r gene 在 Growing up 'big boned': MC4R gene and obesity 的相關結果
Digging a little deeper, the melanocortin-4 receptor (MC4R gene) is a receptor that binds to a hormone called α-MSH, ... ... <看更多>
mc4r gene 在 MC4R gene cDNA ORF clone, Homo sapiens(human) 的相關結果
The following MC4R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein ... ... <看更多>
mc4r gene 在 An evidence-based framework to evaluate Melanocortin-4 ... 的相關結果
Variants in genes associated with the MC4R pathway can result in rare genetic diseases of obesity. Clinical data in patients with certain genetic defects in the ... ... <看更多>
mc4r gene 在 New treatment for obesity caused by rare genetic disorders 的相關結果
POMC, PCSK1 or LEPR deficiency affect the melanocortin 4 receptor (MC4R) pathway which is responsible for transmission of signals about when ... ... <看更多>
mc4r gene 在 MC4R Inhibitor, Agonist, Antagonist, Gene 的相關結果
MedChemExpress provides MC4R Inhibitor, Agonist, Antagonist, Gene, Mechanism of Action, With high purity and quality, excellent customer reviews, ... ... <看更多>
mc4r gene 在 Variation in the MC4R Gene Is Associated with Bone ... 的相關結果
Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women. Gaurav Garg, Jitender Kumar, Fiona E. McGuigan, Martin Ridderstråle, ... ... <看更多>
mc4r gene 在 MC4R | Test catalog 的相關結果
The MC4R gene is associated with autosomal dominant and autosomal recessive obesity due to melanocortin 4 receptor deficiency (MedGen UID: 903905). ... <看更多>
mc4r gene 在 The Human MC4R Promoter - American Diabetes Association 的相關結果
Heterozygous mutations in the coding sequence of the serpentine melanocortin 4 receptor (MC4R) are the most frequent genetic cause of severe ... ... <看更多>
mc4r gene 在 Gene MC4R : melanocortin 4 receptor in Sus scrofa 的相關結果
Symbol: MC4R. Description: melanocortin 4 receptor. Type of gene: protein-coding. Comment: Kim et al. (2000) physically mapped this locus to ... ... <看更多>
mc4r gene 在 MC4R Single Gene 的相關結果
Sequence variants and/or copy number variants (deletions/duplications) within the MC4R gene will be detected with >99% sensitivity. ... <看更多>
mc4r gene 在 MC4R Single Nucleotide Polymorphisms Were Associated ... 的相關結果
Our data first suggest that SNPs in the rs2331841 site of the MC4R gene are closely related to obesity and its related metabolic disorders in ... ... <看更多>
mc4r gene 在 MC4R Gene Associated with Body Mass 的相關結果
You'd gain weight, that's what. It's long been known that mutations in a gene called MC4R cause mice to become bigger and fatter than their ... ... <看更多>
mc4r gene 在 Identification of MC4R gene markers in Bligon goats with ... 的相關結果
Two DNA polymorphisms of the MC4R gene were known within the exon1 region (g.998A/G and g.1079C/T). Genetic diversity was calculated using the Hardy-Weinberg ... ... <看更多>
mc4r gene 在 An Association between Diet and MC4R Genetic ... 的相關結果
The melanocortin-4 receptor (MC4R) gene harbours one of the strongest susceptibility loci for obesity and obesity-related metabolic consequences. ... <看更多>
mc4r gene 在 Mutations in the Melanocortin 4 Receptor (MC4R) Gene in ... 的相關結果
Considering that obesity may have a genetic cause, gene panel testing was applied and heterozygous sporadic variant c.206T> G, p.I69R was detected in the MC4R ... ... <看更多>
mc4r gene 在 A Novel Melanocortin 4 Receptor (Mc4R) Gene Mutation ... 的相關結果
As part of our ongoing project entitled 'Turkish Obesity Genome Study' we determined the nucleotide sequence of the entire coding region of the MC4R gene in 40 ... ... <看更多>
mc4r gene 在 Tissue expression of MC4R - Summary 的相關結果
Disease related genes. FDA approved drug targets. G-protein coupled receptors. Human disease related genes. Transporters. Predicted location i. ... <看更多>
mc4r gene 在 Melanocortin 4 receptor (Mc4r) gene polymorphism and its ... 的相關結果
Melanocortin 4 receptor (Mc4r) gene polymorphism and its association with body ... DNA Analysis, FTA Cards, Genetic Variation, PCR-RFLP, ... ... <看更多>
mc4r gene 在 Evaluation of the Obesity Genes FTO and MC4R for ... 的相關結果
However, rs17782313 of the MC4R gene was associated with LAA stroke susceptibility in smokers (rs17782313: p = 0.020, OR (95% CI) = 1.55 (1.07- ... ... <看更多>
mc4r gene 在 Identification of MC4R gene and its association with body ... 的相關結果
MC4R gene is known as an important candidate gene for the growth trait. The purpose of this research was to identify the MC4R gene in Kebumen Ongole grade ... ... <看更多>
mc4r gene 在 Suppressed and Stimulated Melanocortin-4 Receptor ( ... 的相關結果
This review presents phenotypical characterization and prevalence of the. MC4R gene mutations. Genome-wide association studies revealed that MC4R gene is ... ... <看更多>
mc4r gene 在 Association of MC4R Gene Polymorphisms with Growth ... 的相關結果
Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, energy ... ... <看更多>
mc4r gene 在 Polymorphism in the Melanocortin-4 Receptor (MC4R) ... 的相關結果
Polymorphism in the Melanocortin-4 Receptor (MC4R). Gene and its Effect on Fatness and Weight. Performance of Philippine Native Pigs: A Preliminary Study. ... <看更多>
mc4r gene 在 Comparison Study of Melanocortin 4 Receptor in Cattle ... 的相關結果
Abstract: Melanocortin 4 receptor (MC4R) is a candidate gene for growth traits in the ruminant. The objective of this study to identify variation of the ... ... <看更多>
mc4r gene 在 Gs-independent signalling of melanocortin-4 receptors 的相關結果
In line with this notion, mutations in the MC4R gene are the most frequent monogenic cause of severe obesity in human beings. Surprisingly, MC4R mutations ... ... <看更多>
mc4r gene 在 c.92C>T) Is Associated with Diabetes 的相關結果
Human genome-wide association studies have identified genes associated with obesity and DM, including melanocortin 4 receptor. (MC4R), which plays an important ... ... <看更多>
mc4r gene 在 MC4R gene polymorphism and its association with meat ... 的相關結果
MC4R is expressed in the central nervous system (thalamus, hypothalamus, spinal cord, and cortex), mainly in the hypothalamic region, and it ... ... <看更多>
mc4r gene 在 Deletion of the MC4R Gene in a 9-Year-Old Obese Boy 的相關結果
Abstract Background: The most common monogenic form of obesity is caused by mutations in the melanocortin 4 receptor (MC4R) gene. ... <看更多>
mc4r gene 在 Liraglutide Treatment in a Morbidly Obese Adolescent with ... 的相關結果
Melanocortin-4 receptor gene (MC4R) defects cause monogenic obesity. In this situation, management of obesity is challenging because. ... <看更多>
mc4r gene 在 Genetic Analysis Using Partial Sequencing of ... - Journal IPB 的相關結果
The primers were constructed on the Capra hircus MC4R gene sequence from GenBank (accession No. NM_001285591). Two DNA polymorphisms of MC4R ... ... <看更多>
mc4r gene 在 The Relation between Childhood Obesity and MC4R Gene ... 的相關結果
Many researchers reported MC4R gene and near MC4R region polymorphisms to predispose monogenic obesity both in children and adults. In this study we. ... <看更多>
mc4r gene 在 Combined effect of FTO and MC4R gene polymorphisms ... 的相關結果
Background and Objectives: Fat mass and obesity-associated (FTO) and melanocortin 4 receptor (MC4R) genes associated with obesity have been identified ... ... <看更多>
mc4r gene 在 Association between the Melanocortin-4 Receptor (MC4R) ... 的相關結果
Melanocortin-4 receptor (MC4R) gene has been known as a candidate gene for growth traits in livestock. This research was aimed to identify the polymorphism ... ... <看更多>
mc4r gene 在 SNPs detected in the yak MC4R gene and their association ... 的相關結果
Sequencing of the coding region of the MC4R gene for 354 yaks identified the following five single nucleotide polymorphisms (SNPs): SNP1 (273C>T), ... ... <看更多>
mc4r gene 在 Evaluation of the MC4R gene across eMERGE ... - Mayo Clinic 的相關結果
Fingerprint. Dive into the research topics of 'Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants'. ... <看更多>
mc4r gene 在 Restriction Mapping of MC4R Gene on Bali Cattle ( Bos ... 的相關結果
Restriction Mapping of MC4R Gene on Bali Cattle ( Bos sondaicus ) as Genetic Marker for Breeding Program in Compared to Bos taurus and Bos indicus. ... <看更多>
mc4r gene 在 Evaluation of the porcine melanocortin 4 receptor (MC4R) ... 的相關結果
In a previously performed genome scan based on a Hamp- shire × Landrace cross, we detected one quantitative trait loci (QTL) affecting carcass fat/ meat ratio ... ... <看更多>
mc4r gene 在 Association of MC4R Gene Polymorphisms with Growth ... 的相關結果
Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, ... ... <看更多>
mc4r gene 在 An Association between Diet and MC4R Genetic ... 的相關結果
Abstract: The melanocortin-4 receptor (MC4R) gene harbours one of the strongest susceptibility loci for obesity and obesity-related metabolic ... ... <看更多>
mc4r gene 在 Influence of silencing the MC4R gene by ... 的相關結果
Influence of silencing the MC4R gene by lentivirusmediated RNA interference in bovine fibroblast cells. RJ Yang. M Huang. JY Li. X Gao ... ... <看更多>
mc4r gene 在 Melatonin for an obese child with MC4R gene variant ... 的相關結果
Abnormalities in the melanocortin receptor 4 (MC4R) gene often lead to obesity, but are rarely associated with other conditions such as epilepsy ... ... <看更多>
mc4r gene 在 MC4R And MC3R Mutations 的相關結果
The MC4R is a 332 amino acid protein encoded by a single exon gene localized in chromosome 18q22 (4). It belongs to the family of seven transmembrane G-protein ... ... <看更多>
mc4r gene 在 A C1069G SNP of the MC4R gene and its association ... 的相關結果
In the present study, we identified the MC4R gene in native Korean brown, brindle, and black cattle by polymerase chain reaction restriction fragment length ... ... <看更多>
mc4r gene 在 Haploinsufficiency-of-the-melanocortin-4-receptor-gene-in- ... 的相關結果
gene results in haploinsufficiency-induced obesity, then individuals with deletions of 18q whose deletions include the MC4R gene should be obese in ... ... <看更多>
mc4r gene 在 Association of MC4R (rs17782313) gene polymorphism ... 的相關結果
AbstractBackground and aimsThe association of melanocortin receptor 4 ( MC4R) gene with adiposity measures is widely studied in European populations. ... <看更多>
mc4r gene 在 Melanocortin-4 Receptor (MC4R) gene polymorphism and its ... 的相關結果
Melanocortin-4 Receptor (MC4R) gene polymorphism and its effect on growth traits in Madura cattle. ... <看更多>
mc4r gene 在 Genetic Analysis Using Partial Sequencing of Melanocortin ... 的相關結果
The aim of this research was to perform genetic analysis of MC4R gene sequences from Bligon goats. Fourty blood samples of Bligon does were used for DNA ... ... <看更多>
mc4r gene 在 Liraglutide Treatment Experience in Morbid Obese ... 的相關結果
Variants of the melanocortin-4 receptor (MC4R) gene are the most common cause of monogenic obesity. In this situation;. ... <看更多>
mc4r gene 在 DAYBREAK: Phase 2 Study in Patients With Specific Gene ... 的相關結果
To evaluate the proportion of obese patients with genetic defects in the melanocortin-4 receptor (MC4R) pathway who achieve a clinically ... ... <看更多>
mc4r gene 在 Variation in the MC4R Gene Is Associated with Bone ... 的相關結果
Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish ... of bone strength and both phenotypes have a strong genetic component. ... <看更多>
mc4r gene 在 DNA polymorphisms of the Hu sheep melanocortin-4 receptor ... 的相關結果
In pigs and cattle, MC4R mutations have been identified as genetic markers for growth and traits. Compared with abundant research conducted on. ... <看更多>
mc4r gene 在 MC4R Mutation in Early-onset Severe Childhood Obesity— ... 的相關結果
MC4R (OMIM#155541) encodes a 332 amino acids protein possessing the typical GPCR structural design, having three intact and functional domains; ... ... <看更多>
mc4r gene 在 the-asp298asn-missense-mutation-in-the-porcine- ... 的相關結果
melanocortin-4 receptor (MC4R) gene can be used to affect growth and carcass traits without an effect on meat quality. K. Van den Maagdenberg. ... <看更多>
mc4r gene 在 The rs483145 polymorphism of MC4R gene is not ... 的相關結果
1 / 8 Pages. Previous article. Go back to website. Next article. If you have problems to see the content please click here. ... <看更多>
mc4r gene 在 This Genetic Mutation Makes People Feel Full — All the Time 的相關結果
People with MC4R mutations tend to be obese. Researchers have recorded as many as 300 mutations in this gene, and they are the most common ... ... <看更多>
mc4r gene 在 Melanocortin 4 receptor mutations contribute to the ... 的相關結果
Currently, the genetic basis of population level differences in ... in conserved residues of the melanocortin 4 receptor (MC4R) gene, ... ... <看更多>
mc4r gene 在 Genetic variants that protect against obesity and type 2 ... 的相關結果
People who have genetic variants that disrupt this receptor gain weight easily. A team of scientists looked at the MC4R gene in UK Biobank ... ... <看更多>
mc4r gene 在 Discovery of genetic variants that protect against obesity ... 的相關結果
One of the genes that is known to play a key role in regulating weight ... They found that MC4R gene variants linked to higher obesity risk ... ... <看更多>
mc4r gene 在 Association of the rs17782313, rs17773430 and ... 的相關結果
Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish ... ... <看更多>
mc4r gene 在 MC4R Gene and Obesity Risk: A Systematic Review and 的相關結果
Background: Genome-wide association studies on Europeans have shown that two polymorphisms (rs17782313, rs12970134) near the melanocortin 4 ... ... <看更多>
mc4r gene 在 Genes and obesity 的相關結果
The most commonly implicated gene is MC4R, which encodes the melanocortin 4 receptor. ... In most obese people, no single genetic cause can be identified. ... <看更多>
mc4r gene 在 Mc4r 的相關結果
protein-coding gene in the species Mus musculus. Mc4-r; melanocortin 4 receptor; Pkcp. In more languages. Spanish. Mc4r. gen de la especie Mus musculus. ... <看更多>
mc4r gene 在 Pathophysiology of Rare Genetic Diseases of Obesity 的相關結果
Explore the impact of melanocortin-4 receptor (MC4R) pathway and it's role in maintaining a healthy body weight. ... <看更多>
mc4r gene 在 4160 - Gene ResultMC4R melanocortin 4 receptor [ (human)] 的相關結果
Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical ... ... <看更多>